Results 241 to 250 of about 6,396,790 (306)

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Associations of bulk tank milk free fatty acid concentration with farm type and time of year. [PDF]

JDS Commun
Woodhouse HM, LeBlanc SJ, DeVries TJ, Hand KJ, Kelton DF.   +4 more
europepmc   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists. [PDF]

Drug Des Devel Ther
Liu L, Zhang Q, Ma Y, Lin L, Liu W, Ding A, Wang C, Zhou S, Cai J, Tang H.   +9 more
europepmc   +1 more source

CD36 serves as a signaling receptor and free fatty acid (FFA) transporter in dyslipidemia: the role of dapagliflozin and alirocumab in downregulating atherogenic dyslipidemia via FFA uptake inhibition-experimental study. [PDF]

Int J Surg
Yeh JN, Wang YT, Lan XW, Chen YL, Huang CR, Shao PL, Yip HK, Guo J.   +7 more
europepmc   +1 more source

The association of preoperative serum free fatty acid levels with survival in breast cancer patients. [PDF]

Discov Oncol
Li L, Jin L, You L, Liu Q, Yan L.
europepmc   +1 more source

Correction to "Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4". [PDF]

MedComm (2020)
europepmc   +1 more source

Rosa roxburghii Tratt fruit extract ameliorate free fatty acid induced steatosis in HepG2 cells through activating PI3K-Akt and PPAR pathways. [PDF]

Sci Rep
Ling Y, Wang W, Li X, Wang X, Zhang S, Huang S, Zhou H, Peng L, Yin W.   +8 more
europepmc   +1 more source

Assessment of Intestinal Free Fatty Acid Binding Protein 4 in Alopecia Areata Patients. [PDF]

Skin Appendage Disord
Soliman AE, Shaker O, El-Tahlawi SM, Abdaltwab Mahgoub G, Yaseen SM.   +4 more
europepmc   +1 more source

Association between milk pump type and free fatty acid concentrations on dairy farms with automated milking systems. [PDF]

JDS Commun
Woodhouse HM, LeBlanc SJ, DeVries TJ, Hand KJ, Kelton DF.   +4 more
europepmc   +1 more source