Results 201 to 210 of about 387,909 (263)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Genome-scale CRISPRi screen identifies pcnB repression conferring improved physiology for overproduction of free fatty acids in Escherichia coli. [PDF]

Nat Commun
Fang L, Hao X, Fan J, Liu X, Chen Y, Wang L, Huang X, Song H, Cao Y.   +8 more
europepmc   +1 more source

A Comprehensive Study for Determination of Free Fatty Acids in Selected Biological Materials: A Review. [PDF]

Foods
Uçar B, Gholami Z, Svobodová K, Hradecká I, Hönig V.   +4 more
europepmc   +1 more source

Free fatty acids: independent predictors of long-term adverse cardiovascular outcomes in heart failure patients. [PDF]

Lipids Health Dis
Liao GZ, Liu HH, He CH, Feng JY, Zhuang XF, Wang JX, Zhou P, Huang Y, Zhou Q, Zhai M, Zhang YH, Zhang J.   +11 more
europepmc   +1 more source

Determination of free fatty acids and volatile compounds of butter oil produced from pasteurized and unpasteurized butter at different temperatures. [PDF]

Food Sci Nutr
Demir T, Andiç S, Oğuz Ş.
europepmc   +1 more source

Effect of physical activity on free fatty acids, insulin resistance, and blood pressure in obese older women. [PDF]

Phys Act Nutr
Son WH, Ha MS, Park TJ.
europepmc   +1 more source

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Free fatty acids and exercise

The American Journal of Clinical Nutrition, 1993
Although the great explorers were well aware that eating fat was an efficient way to meet their large energy demand, it was not until some decades into this century that it could be demonstrated that lipids are metabolized directly by contracting skeletal muscles.
B, Saltin, P O, Astrand
openaire   +2 more sources

The effect of free fatty acids on oxygen consumption in man: the free fatty acid hypothesis

Scandinavian Journal of Clinical and Laboratory Investigation, 1980
The effect on total body O2 consumption of induced changes in plasma free fatty acids (FFA) was studied in sixteen healthy men. In the first group (n = 5) plasma FFA was augmented by intravenous infusion of a triglyceride emulsion and heparin, increasing FFA from 0.522±0.11 to 3.025±0.357 mmol/l without any change in total O2 consumption or in the ...
J K, Kjekshus, E, Ellekjaer, P, Rinde
openaire   +2 more sources