Results 1 to 10 of about 643,486 (217)

Serum Nonesterified Fatty Acids and Incident Stroke: The CHS [PDF]

Journal of the American Heart Association, 2021
Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies.
, Alice H Lichtenstein, Neil K Huang
exaly   +5 more sources

Nonesterified Fatty Acids, Albumin, and Platelet Aggregation [PDF]

Diabetes, 2015
It has been known for five decades that nonesterified fatty acids (NEFAs) have a role in the activation of platelets and thrombosis. Thus, the infusion of NEFAs leads to massive thrombosis and platelet activation (1–4). It has also been shown that their binding to albumin protects the platelets from activation (5).
Sandeep Dhindsa, Husam Ghanim
exaly   +4 more sources

Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues

Scientific Reports, 2021
Colorectal cancer (CRC) is a major cancer, and its precise diagnosis is especially important for the development of effective therapeutics. In a series of metabolome analyses, the levels of very long chain fatty acids (VLCFA) were shown to be elevated in
Kotaro Hama, Yuko Fujiwara, Tamuro Hayama, Tsuyoshi Ozawa, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi, Kazuaki Yokoyama   +7 more
doaj   +2 more sources

The effects of saturated fatty acid supplements on plasma and milk concentration of fatty acid esters of hydroxy fatty acids in dairy cows [PDF]

JDS Communications
Fatty acid esters of hydroxy fatty acids (FAHFA) are a novel class of bioactive lipids with demonstrated antidiabetic and anti-inflammatory properties in rodent models and humans but have not been investigated in cows.
M. Arif, B.A. Harsch, C. Matamoros, I.J. Salfer, R. Shepardson, K.J. Harvatine   +5 more
doaj   +2 more sources

Quantitative extraction and determination of nonesterified fatty acids in plasma

Journal of Lipid Research, 1973
A method is described for the determination of nonesterified fatty acids in plasma. Extraction is at least 98% efficient, and losses during subsequent stages are corrected for by the use of an internal radioactive standard.
W.G. Duncombe, T.J. Rising
doaj   +3 more sources

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health
Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in periparturient dairy cows.
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
doaj   +2 more sources

G Protein-Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models. [PDF]

Obesity (Silver Spring)
This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Sun X, Mahler C, Stull ND, Nasiri A, Zhou B, Samuel V, Shulman G, Flak JN, Ren H.   +8 more
europepmc   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Substrate modulation of fatty acid effects on energization and respiration of kidney proximal tubules during hypoxia/reoxygenation. [PDF]

PLoS ONE, 2014
Kidney proximal tubules subjected to hypoxia/reoxygenation develop a nonesterified fatty acid-induced energetic deficit characterized by persistent partial mitochondrial deenergization that can be prevented and reversed by citric acid cycle substrates ...
Anja Bienholz, Ahmad Al-Taweel, Nancy F Roeser, Andreas Kribben, Thorsten Feldkamp, Joel M Weinberg   +5 more
doaj   +1 more source

Regulation of Insulin Clearance by Non-Esterified Fatty Acids

Biomedicines, 2022
Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in
Sonia M. Najjar, Raziyeh Abdolahipour, Hilda E. Ghadieh, Marziyeh Salehi Jahromi, John A. Najjar, Basil A. M. Abuamreh, Sobia Zaidi, Sivarajan Kumarasamy, Harrison T. Muturi   +8 more
doaj   +1 more source