Results 41 to 50 of about 4,701,570 (260)

Biochemical changes associated with the fermentation of baobab seeds in Maari: An alkaline fermented seeds condiment from western Africa

Journal of Ethnic Foods, 2015
Chemical changes during the fermentation of baobab seeds for production of Maari, a food condiment used in West Africa, were studied. Results showed a wide variety of free amino acids including essential amino acids in the unfermented seeds. Fermentation
Charles Parkouda, Fatoumata Ba/Hama, Laurencia Ouattara/Songre, Kwaku Tano-Debrah, Bréhima Diawara   +4 more
doaj   +1 more source

Cell-free metabolic engineering enables selective biotransformation of fatty acids to value-added chemicals

Metabolic Engineering Communications, 2023
Fatty acid-derived products such as alkanes, fatty aldehydes, and fatty alcohols have many applications in the chemical industry. These products are predominately produced from fossil resources, but their production processes are often not ...
Yushi Liu, Wan-Qiu Liu, Shuhui Huang, Huiling Xu, Haofan Lu, Changzhu Wu, Jian Li   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress [PDF]

, 2010
Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact ...
Degenhardt, Tatjana, Boekschoten, M.V., Kersten, A.H., Boekschoten, Mark V., Georgiadi, Anastasia, Lichtenstein, Laeticia, Müller, Michael, Georgiadi, A., Bilsen, M., van, van Bilsen, Marc, Müller, M.R., Lichtenstein, L.L., Desvergne, Beatrice, Degenhardt, T., Desvergne, B., Boekschoten, Mark V, van Bilsen, M., Kersten, Sander, Kersten, S., Müller, M., Lichtenstein, L.   +20 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]

, 1992
Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Sven Fischer, Seifferth, Bernd, Paumgartner, Gustav, Holl, Joseph, Frieder Berr, Werner Richter, Joseph Holl, Bernd Seifferth, Jüngst, Dieter, Dieter Jongst, Berr, Frieder, Richter, Werner O., Fischer, Sven, Gustav Paumgartner   +13 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source