Results 51 to 60 of about 387,549 (311)
Free fatty acids cause podocytes dysfunction and inflammation
Journal of Biological Research, 2023 The mechanisms underlying obesity-related kidney disease are not well understood. Growing evidence suggests that free fatty acids (FFAs), a cause of oxidative stress, play an important role in obesity and its related complications.
Anna Laura Colia +5 more
doaj +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Grasas y Aceites, 2002 “Chorizo de cebolla” is a traditional sausage made in the north west of Spain. In four batches manufactured by artisanal methods and 4 manufactured by industrial ones the contents of total and free fatty acids were assessed throughout ripening, taking ...
Inmaculada Franco +3 more
doaj +1 more source
Journal of Investigative Dermatology, 1974 According In our current state of knowledge, free fatty acids are formed in sebaceous follicles primarily through hydrolysis of sebum triglycerides by microbial lipases. Because of their comedogenic and irritant qualities, these free fatty acids are probably responsible for many of the alterations in the follicle that result in acne lesions.
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of Lipid Research, 1981 A rapid and sensitive method for the analysis of plasma free fatty acids with glass capillary column gas-liquid chromatography and flame ionization detection is described. The plasma sample, together with n-pentadecanoic acid as an internal standard, was
K Y Tserng +3 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Obesity-induced asthma: Role of free fatty acid receptors
Japanese Dental Science Review, 2019 Obesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling.
Kentaro Mizuta +4 more
doaj +1 more source
An Overview of Hormone-Sensitive Lipase (HSL)
The Scientific World Journal, 2022 Hormone-sensitive lipase (HSL) is a pivotal enzyme that mediates triglyceride hydrolysis to provide free fatty acids and glycerol in adipocytes in a hormonally controlled lipolysis process.
Arwa R. Althaher
doaj +1 more source