Results 1 to 10 of about 409,071 (262)

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities

Antioxidants, 2022
Currently, plasma medicine is a synthetic direction that unites the efforts of specialists of various profiles. For the successful formation of plasma medicine, it is necessary to solve a large complex of problems, including creating equipment for ...
Andrew K. Martusevich, Alexandra V. Surovegina, Ivan V. Bocharin, Vladimir V. Nazarov, Inessa A. Minenko, Mikhail Yu. Artamonov   +5 more
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Pharmacologic Ascorbate and DNMT Inhibitors Increase DUOX Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer

Antioxidants, 2023
Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes.
Garett J. Steers, Brianne R. O’Leary, Juan Du, Brett A. Wagner, Rory S. Carroll, Frederick E. Domann, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen   +8 more
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Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients

Journal of Biomedical Science, 2023
Background Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the m.8344A > G mutation in mitochondrial tRNALys gene, and usually manifested as complex neurological disorders and muscle ...
Yu-Ting Wu, Hui-Yi Tay, Jung-Tse Yang, Hsiao-Hui Liao, Yi-Shing Ma, Yau-Huei Wei   +5 more
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Acute inhibition of OGA sex-dependently alters the networks associated with bioenergetics, autophagy, and neurodegeneration

Molecular Brain, 2022
The accumulation of neurotoxic proteins characteristic of age-related neurodegenerative pathologies such as Alzheimer’s and Parkinson’s diseases is associated with the perturbation of metabolism, bioenergetics, and mitochondrial quality control.
Van N. Huynh, Gloria A. Benavides, Michelle S. Johnson, Xiaosen Ouyang, Balu K. Chacko, Edie Osuma, Toni Mueller, John Chatham, Victor M. Darley-Usmar, Jianhua Zhang   +9 more
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Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound

Applied Sciences, 2022
The aim of this work was the comparative estimation of the efficiency of different variants of local ozone therapy in experimental burn wound. We conducted the experiments on 45 white Wistar rats being randomized for three groups.
Andrew K. Martusevich, Andrey A. Struchkov, Vladimir V. Nazarov, Alexandra S. Fedotova, Mikhail Yu. Artamonov, Sergey P. Peretyagin   +5 more
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Neutrophil NET Formation with Microbial Stimuli Requires Late Stage NADPH Oxidase Activity

Antioxidants, 2021
Neutrophils respond to a range of stimuli by releasing extracellular traps (NETs), a mesh consisting of chromatin plus granule and cytoplasmic proteins.
Heather A. Parker, Harry M. Jones, Christopher D. Kaldor, Mark B. Hampton, Christine C. Winterbourn   +4 more
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Effect of Expression of Nuclear-Encoded Cytochrome C Oxidase Subunit 4 Isoforms on Metabolic Profiles of Glioma Cells

Metabolites, 2022
Although often effective at treating newly diagnosed glioblastoma (GBM), increasing evidence suggests that chemo- and radiotherapy-induced alterations in tumor metabolism promote GBM recurrence and aggressiveness, as well as treatment resistance.
Claudia R. Oliva, Md Yousuf Ali, Susanne Flor, Corinne E. Griguer   +3 more
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Mitoferrin, Cellular and Mitochondrial Iron Homeostasis

Cells, 2022
Iron is essential for many cellular processes, but cellular iron homeostasis must be maintained to ensure the balance of cellular signaling processes and prevent disease.
Md Yousuf Ali, Claudia R. Oliva, Susanne Flor, Corinne E. Griguer   +3 more
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COX4-1 promotes mitochondrial supercomplex assembly and limits reactive oxide species production in radioresistant GBM

Cell Stress, 2022
Glioblastoma (GBM) is a fatal disease with recurrences often associated with radioresistance. Although often effective at treating newly diagnosed GBM, increasing evidence suggests that radiotherapy-induced alterations in tumor metabolism promote GBM ...
Claudia R. Oliva, Md Yousuf Ali, Susanne Flor, Corinne E. Griguer   +3 more
doaj   +1 more source

Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia

Frontiers in Oncology, 2021
Loss-of-function mutations in the DNA demethylase TET2 are associated with the dysregulation of hematopoietic stem cell differentiation and arise in approximately 10% of de novo acute myeloid leukemia (AML). TET2 mutations coexist with other mutations in
Carlos C. Smith-Díaz, Nicholas J. Magon, Judith L. McKenzie, Mark B. Hampton, Margreet C. M. Vissers, Andrew B. Das   +5 more
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