Results 11 to 20 of about 409,071 (262)
Antioxidants, 2022 The review presents evidence that the main damage to the vascular wall occurs not from the action of “oxidized” LDL, which contain hydroperoxy acyls in the phospholipids located in their outer layer, but from the action of LDL particles whose apoprotein ...
Vadim Z. Lankin +2 more
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O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease
Molecular Brain, 2017 Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses.
Willayat Y. Wani +8 more
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Hypothiocyanous Acid Disrupts the Barrier Function of Brain Endothelial Cells
Antioxidants, 2022 Inflammation is a common feature of neurological diseases. During neuroinflammation, neutrophils are recruited to the brain vasculature, where myeloperoxidase can produce hypochlorous acid and the less well-studied oxidant hypothiocyanous acid (HOSCN ...
Eveline van Leeuwen +2 more
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Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
Redox Biology, 2014 Oxidative stress including DNA damage, increased lipid and protein oxidation, are important features of aging and neurodegeneration suggesting that endogenous antioxidant protective pathways are inadequate or overwhelmed.
Samantha Giordano +2 more
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Auranofin and Pharmacologic Ascorbate as Radiomodulators in the Treatment of Pancreatic Cancer
Antioxidants, 2022 Pancreatic cancer accounts for nearly one fourth of all new cancers worldwide. Little progress in the development of novel or adjuvant therapies has been made over the past few decades and new approaches to the treatment of pancreatic cancer are ...
Garett J. Steers +5 more
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Journal of Biomedical Science, 2017 Metabolic diseases such as obesity, type 2 diabetes (T2D) and insulin resistance have attracted great attention from biomedical researchers and clinicians because of the astonishing increase in its prevalence.
Chih-Hao Wang, Yau-Huei Wei
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Journal of Chemistry, 2022 A series of seventeen cinnamic acid hybrids (4ai–ci) were obtained through an amidation of aminoadamantanes (amantadine, rimantadine, and memantine) with mixed anhydride generated from different substituted cinnamic acid and ethyl chloroformate.
Maya Chochkova +9 more
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Evaluating the iron chelator function of sirtinol in non-small cell lung cancer
Frontiers in Oncology, 2023 A distinctive feature of cancer is the upregulation of sirtuin proteins. Sirtuins are class III NAD+-dependent deacetylases involved in cellular processes such as proliferation and protection against oxidative stress. SIRTs 1 and 2 are also overexpressed
Michael S. Petronek +6 more
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Stability of aqueous solutions of ascorbate for basic research and for intravenous administration
Advances in Redox Research, 2023 Ascorbate (vitamin C) can rapidly oxidize in many near-neutral pH, aqueous solutions. We report on the stability of ascorbate solutions prepared for infusion into patients using standard pharmacy protocols, for example, 75 g of ascorbate/L in water for ...
Brett A. Wagner, Garry R. Buettner
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Frontiers in Aging, 2021 O-linked conjugation of ß-N-acetyl-glucosamine (O-GlcNAc) to serine and threonine residues is a post-translational modification process that senses nutrient availability and cellular stress and regulates diverse biological processes that are involved in ...
Van N Huynh +11 more
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