Results 131 to 140 of about 640,753 (304)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Combination of Analytical Pyrolysis and fractionation of technical lignin as a tool for improvement of its antioxidant properties [PDF]
, 2012 Antioxidant properties of parent lignin and its fractions was assessed in the tests with free radicals ABTS•+ and DPPH. Increasing ratio between content of syringyl and guaiacyl substructures and the extent of conjugation of lignin macromolecule (Py-GC ...
Arshanitsa, Alexandr +4 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Saturated hydrocarbon polymeric binder for advanced solid propellant and hybrid solid grains Quarterly report no. 2, 1 Feb. - 30 Apr. 1966 [PDF]
Synthesis and analysis of ethylene-neohexene copolymers with other non ketene-imine group free radicals for solid and hybrid grain propellant saturated hydrocarbon binder ...
Ashcraft, A. C., Jr. +3 more
core +1 more source
High temperature decomposition of hydrogen peroxide [PDF]
, 2004 Nitric oxide (NO) is oxidized into nitrogen dioxide (NO.sub.2) by the high temperature decomposition of a hydrogen peroxide solution to produce the oxidative free radicals, hydroxyl and hydroperoxyl.
Parrish, Clyde F.
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Evaluation of the Antioxidant Activity of New Coumarin Derivatives by Cyclic Voltammetry [PDF]
, 2010 Free radicals, species with one or more unpaired electrons are produced in normal or pathological cell metabolism, from xenobiotics, or trough ionizing radiation.
Martins, Sérgio +3 more
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