Results 71 to 80 of about 5,663,581 (403)

Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo [PDF]

, 2017
Natural antioxidants derived from plants have shown a tremendous inhibitory effect on free radicals in actively metabolizing cells. Overproduction of free radicals increases the risk factor of chronic diseases associated with diabetes, cancer, arthritis ...
Hashim, Z., Ismail, H. F., Majid, F. A. A., Rahman, N. S. A., Soon, W. T., Zainudin, A. N.   +5 more
core   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Reactive Oxygen and Nitrogen Species in Plants

Antioxidants
Reactive oxygen and nitrogen species (ROS and RNS) include two families of molecules that, in recent years, have been shown to be involved in a wide range of biological functions, such as seed and pollen germination, the development and regulation of ...
Francisco J Corpas, José M. Palma
doaj   +1 more source

AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS [PDF]

, 2010
While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials.
Bok Yun, Byoung Gwag, Doo Im, Jae Lee, Jin Lee, Jin Shin, Joe Springer, Soo Byun, Sun Park, Sun Son, Woong Cho, Yong Lee, Young Lee   +12 more
core   +1 more source

Real-time dynamics of the formation of hydrated electrons upon irradiation of water clusters with extreme ultraviolet light [PDF]

, 2019
Free electrons in a polar liquid can form a bound state via interaction with the molecular environment. This so-called hydrated electron state in water is of fundamental importance e.g.~in cellular biology or radiation chemistry.
Bohlen, M., Callegari, C., Clark, A., Coreno, M., Di Fraia, M., Drabbels, M., Finetti, P., Huppert, M., Laforge, A. C., Ma, J., Michiels, R., Mudrich, M., Oliver, V., Plekan, O., Prince, K. C., Shcherbinin, M., Stienkemeier, and F., Stranges, S., Svoboda, V., von Conta, A., Wörner, H. J.   +20 more
core   +2 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Combined Electron Magnetic Resonance and Density Functional Theory Study of Thermally Induced Free Radical Reactions in Fructose and Trehalose Single Crystals [PDF]

, 2009
Both as models for studying the effects of radiation on the DNA sugar unit and for applications in dosimetry, radiation-induced defects in sugars have in the past few decades been intensively studied with electron magnetic resonance (EMR) techniques ...
Callens, Freddy, De Cooman, Hendrik, Pauwels, Ewald, Sagstuen, E., Tarpan, Mihaela Adeluta, Waroquier, Michel   +5 more
core  

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Airways oxidative stress, lung function and cognitive impairment in aging. [PDF]

, 2010
BACKGROUND: An altered balance of oxidants/antioxidants is one of the pathological mechanisms of many age-dependent disorders. We aimed to investigate the age-related airways oxidative stress, using non invasive, safe and repeatable techniques; to ...
Cagnazzo, Mg, Carpagnano, Ge, Foschino Barbaro, M. P., Gramiccioni, C, Spanevello, Antonio, Turchiarelli, V   +5 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source