Results 81 to 90 of about 3,933,717 (303)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 1988 This volume covers the proceedings of the Fifth International Symposium on Organic Free Radicals in Zürich/Switzerland, September 18 - 23, 1988.
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Plant peroxisomes: A nitro-oxidative cocktail
Redox Biology, 2017 Although peroxisomes are very simple organelles, research on different species has provided us with an understanding of their importance in terms of cell viability.
Francisco J. Corpas +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Mitochondrial DNA: Radically free of free-radical driven mutations
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2015 Mitochondrial DNA has long been posited as a likely target of oxidative damage induced mutation during the ageing process. Research over the past decades has uncovered the accumulation of mitochondrial DNA mutations in association with a mosaic pattern of cells displaying mitochondrial dysfunction in ageing individuals.
Kauppila, Johanna H.K. +1 more
openaire +3 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
FREE RADICALS IN SCHIZOPHRENIA
Psychiatry and Clinical Psychopharmacology, 2021 Objective: The role of free radicals in schizophrenia has been an issue of concern in recent years. In this study we aimed to investigate the importance of the free radicals and the non-enzymatic antioxidant defense systems in schizophrenic patients ...
Yalçın Güzelhan +3 more
doaj
Journal of Biological Researches, 2016 Breast cancer is the most common cancer in woman. Accumulation of free radical in the body is one of cancer risk factors. Since 2009, Research Institute for Free Radicals Shedding Malang has been developing balur nano divine kretek method, combination of
Dody Novrial +4 more
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, 2008 We investigated the balance of free radicals in retinas at various time points after chronically elevating intraocular pressures in rats. The left eyes of female Wistar rats were divided into five intraocular pressure elevation (IOPE) subgroups after ...
CHEN, CHAU-FONG;MA, MING-CHIEH;KO, MEI- LAN +1 more
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