Results 81 to 90 of about 3,754,131 (296)
Plant peroxisomes: A nitro-oxidative cocktail
Redox Biology, 2017 Although peroxisomes are very simple organelles, research on different species has provided us with an understanding of their importance in terms of cell viability.
Francisco J. Corpas +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
FREE RADICALS IN SCHIZOPHRENIA
Psychiatry and Clinical Psychopharmacology, 2021 Objective: The role of free radicals in schizophrenia has been an issue of concern in recent years. In this study we aimed to investigate the importance of the free radicals and the non-enzymatic antioxidant defense systems in schizophrenic patients ...
Yalçın Güzelhan +3 more
doaj
Mitochondrial DNA: Radically free of free-radical driven mutations
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2015 Mitochondrial DNA has long been posited as a likely target of oxidative damage induced mutation during the ageing process. Research over the past decades has uncovered the accumulation of mitochondrial DNA mutations in association with a mosaic pattern of cells displaying mitochondrial dysfunction in ageing individuals.
Kauppila, Johanna H.K. +1 more
openaire +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2010 Switching of the spin-spin interactions in organic radicals is of particular interest for the development of molecular-scale magnetic devices and guest-tunable spin materials, such as new spin probe reagents and MRI contrast agents.
LUCARINI, MARCO
core +1 more source
Mit COLOR CRY, RHYTHM, FREE RADICALS und PARTICLES IN SPACE kehrt Lye zur Form seiner frühen abstrakten Filme zurück. Er benutzt auch wieder die Technik des Handmade film.
Lye, Len 1901-1980
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Analiza składu i właściwości mieszanek ziołowych dodawanych do produktów spożywczych typu instant
HerbalismŚwiat nieustannie pędzi do przodu, a my mamy coraz mniej czasu na codzienne czynności, dlatego coraz większą popularność zyskuje „kultura typu instant”. Samo słowo instant oznacza „zaraz”, „szybko”, „od razu”.
Aleksandra Baran +2 more
doaj +1 more source