Results 91 to 100 of about 321,715 (314)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

Functional fluorocarbons via free radical additions to hexafluoropropene [PDF]

open access: yes, 1987
The effect of substituents on the carbon-hydrogen bond reactivity in free radical additions to hexaf1uoropropene has been investegated. Ethers, amines, amides, isocyanates and silanes all give Free radical adducts.
Jones, S. L.
core  

Plant peroxisomes: A nitro-oxidative cocktail

open access: yesRedox Biology, 2017
Although peroxisomes are very simple organelles, research on different species has provided us with an understanding of their importance in terms of cell viability.
Francisco J. Corpas   +3 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi   +7 more
wiley   +1 more source

Free radicals [PDF]

open access: yes, 2017
U ovom završnom radu obrađena je tema o slobodnim radikalima. Poznato je da su slobodni radikali čestice koji imaju nespareni elektron i nastaju homolitičkim cijepanjem kovalentne veze. Slobodni radikali mogu reagirati s alkanima, alkenima, alkinima i sl.
Krijan, Luka
core  

Environmentally Persistent Free Radicals (EPFRs)-2. Are Free Hydroxyl Radicals Generated in Aqueous Solutions? [PDF]

open access: yes, 2016
A chemical spin trap, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), in conjunction with electron paramagnetic resonance (EPR) spectroscopy was employed to measure the production of hydroxyl radical (·OH) in aqueous suspensions of 5% Cu(II)O/silica (3.9% Cu ...
Barry Dellinger (17794)   +1 more
core   +1 more source

Mitochondrial DNA: Radically free of free-radical driven mutations

open access: yesBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2015
Mitochondrial DNA has long been posited as a likely target of oxidative damage induced mutation during the ageing process. Research over the past decades has uncovered the accumulation of mitochondrial DNA mutations in association with a mosaic pattern of cells displaying mitochondrial dysfunction in ageing individuals.
Kauppila, Johanna H.K.   +1 more
openaire   +3 more sources

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas   +3 more
wiley   +1 more source

FREE RADICALS IN SCHIZOPHRENIA

open access: yesPsychiatry and Clinical Psychopharmacology, 2021
Objective: The role of free radicals in schizophrenia has been an issue of concern in recent years. In this study we aimed to investigate the importance of the free radicals and the non-enzymatic antioxidant defense systems in schizophrenic patients ...
Yalçın Güzelhan   +3 more
doaj  

Histologic profile and CD44 expression in breast cancer tissue of balur nano divine kretek volunteers

open access: yesJournal of Biological Researches, 2016
Breast cancer is the most common cancer in woman. Accumulation of free radical in the body is one of cancer risk factors. Since 2009, Research Institute for Free Radicals Shedding Malang has been developing balur nano divine kretek method, combination of
Dody Novrial   +4 more
doaj   +1 more source

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