Results 101 to 110 of about 15,924,848 (336)

The effects of barriers on supershear rupture

Geophysical Research Letters, 2016
A barrier may induce a supershear rupture transition in some cases, whereas it may prevent the further propagation of a supershear rupture in other cases.
Jiankuan Xu, Zhenguo Zhang, Xiaofei Chen
doaj   +1 more source

Computational Fluid Dynamics Analysis of Cavitating Hydrofoils Near the Sea Surface in Supercritical Open Channel Flows [PDF]

Journal of Applied Fluid Mechanics
As a high-speed submerged body travels beneath the water surface, it induces deformation of the free surface and may generate cavitation due to local pressure reductions.
G. Taghinia, A. Esmaeili
doaj   +1 more source

Free form surfaces

, 2000
A method to construct continuous order k surfaces of arbitrary topological type by tracing a mesh that represents a 2-manifold is presented. The presented approach constructs the surface from a collection of pieces which overlap, using the known technology of manifolds. The surface is built from the given mesh and two arbitrary
Cotrina Navau, Josep, Pla García, Núria   +1 more
openaire   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Numerical study of the effect of discharge on flow pattern around a submerged spur dike in an open channel [PDF]

مهندسی منابع آب, 2016
One of the important purposes of river engineering science is to protect river banks from erosion phenomenon and to prevent shifting of the main channel path.
Mohammad Vaghefi, Afshin Eghbalzadeh, Mokhtar Rostamnezhad   +2 more
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Numerical investigation of flow field characteristics over vertical drops with sudden contraction for different contraction ratios [PDF]

Journal of Applied Research in Water and Wastewater
Vertical drops are widely implemented in hydraulic structures such as irrigation canals, wastewater collection systems, and stepped spillways to dissipate flow kinetic energy while enhancing aeration and promoting dissolved oxygen levels.
Hossein Shahin, Afshin Eghbalzadeh, Mitra Javan   +2 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source