Results 111 to 120 of about 40,275 (223)

Free thyroxine index or effective thyroxine ratio?

open access: yesSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977
The ability of the free thyroxine index (FTI) and the effective thyroxine ratio (ETR) to distinguish abnormal from normal thyroid function is compared in a series of 422 patients; they were equally successful in detecting hyperthyroidism. In hypothyroidism, however, the ETR values of 22% were within 95% 'normal' limits compared with 7,4% of the FTI ...
openaire   +1 more source

Safety of 12‐Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 4802-4812, August 2026.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve   +6 more
wiley   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Ultrasensitive Label-Free Detection of Free Thyroxine (T4) in Physiological Ranges Using Aptamer-Functionalized Silicon Nanowire Field Effect Transistors. [PDF]

open access: yesBiosensors (Basel)
Klinghammer S   +7 more
europepmc   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 5030-5047, August 2026.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan   +2 more
wiley   +1 more source

Multi‐Omics‐Guided Design and Safety Engineering of Nucleic Acid Therapeutics: From Molecular Perturbation to Predictive Toxicology and Precision Translation

open access: yesChemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Multi‐omics (proteomics, metabolomics, and single‐cell/spatial transcriptomics) provides a systems framework to distinguish on‐target efficacy from off‐target and toxicity signatures of chemically modified nucleic acid therapeutics, enabling omics‐guided structure–activity and safety optimisation from discovery to clinical translation. ABSTRACT Nucleic
Gurjit Kaur Bhatti   +6 more
wiley   +1 more source

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