Results 111 to 120 of about 3,951,122 (311)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Are items actively removed from working memory during free time in children with developmental language disorder? [PDF]
Int J Lang Commun Disord, 2022 Larson C +3 more
europepmc +1 more source
Creating the Conditions for Free Time in the Debt Economy: On Stealing Time in and through Education
, 2022 Jason Thomas Wozniak
openalex +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A CMOS Integrator-Based Clock-Free Time-to-Digital Converter for Home-Monitoring LiDAR Sensors. [PDF]
Sensors (Basel), 2022 He Y, Park SM.
europepmc +1 more source
Journal of Philosophy, 2015 In this paper I defend two conclusions: that time travel journeys to the past are not undertaken freely and, more generally, that nobody is free between the earliest arrival time and the latest departure time of a time travel journey to the past. Time travel to the past destroys freedom on a global scale.
openaire +3 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
The efficacy of botulinum toxin type-A for intractable chronic migraine patients with no pain-free time. [PDF]
Br J Pain, 2022 Atraszkiewicz D, Ito R, Bahra A.
europepmc +1 more source
TIME-FREE CONTINUOUS PROCESSES [PDF]
Proceedings of the National Academy of Sciences, 1968 openaire +2 more sources