Results 21 to 30 of about 10,376 (110)
Sleep enhances gamma oscillations in the seizure onset zone and broadband activity in the irritative zone of focal cortical dysplasia
Epilepsia Open, EarlyView.Abstract Objective
Focal cortical dysplasia (FCD) is a leading cause of drug‐resistant epilepsy and is associated with sleep‐related seizures, yet the underlying electrophysiological mechanisms during different brain states remain poorly understood. We investigated whether fast oscillations (FOs) within the seizure onset zone (SOZ) and irritative zone (Mohammad F. Khazali, Nina Schwoon, Armin Brandt, Matthias Dümpelmann, Yiwen Li Hegner, Nicolas Roehri, Dirk‐Matthias Altenmüller, Victoria San Antonio‐Arce, Peter C. Reinacher, Julia M. Nakagawa, Soroush Doostkam, Theo Demerath, Horst Urbach, Andreas Schulze‐Bonhage, Marcel Heers +14 morewiley +1 more sourceDuration of Posttraumatic Amnesia Predicts Neuropsychological and Global Outcome in Complicated Mild Traumatic Brain Injury. [PDF]
, 2016 OBJECTIVES: Examine the effects of posttraumatic amnesia (PTA) duration on neuropsychological and global recovery from 1 to 6 months after complicated mild traumatic brain injury (cmTBI).
PARTICIPANTS: A total of 330 persons with cmTBI defined as Glasgow Barber, Jason, Diaz-Arrastia, Ramon, Dikmen, Sureyya S., Hart, Tessa, Hesdorffer, Dale C., Hsu, Nancy H., Jallo, Jack, Novack, Thomas A., Ricker, Joseph, Temkin, Nancy, Zafonte, Ross +10 morecore +2 more sourcesLRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract
A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre +12 morewiley +1 more sourceDiscordance of Dopaminergic Dysfunction and Subcortical Atrophy by α‐Synuclein Status in Sporadic and Genetic Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
Parkinson's disease (PD) is characterized by predominantly neuronal α‐synuclein pathology and dopaminergic dysfunction. Cerebrospinal fluid (CSF) seeding amplification assays (SAA) detect α‐synuclein aggregates in vivo, but not all patients with PD have a positive SAA.Michael Tran Duong, Sandhitsu R. Das, Pulkit Khandelwal, Joaquin A. Vizcarra, Yue Li, Long Xie, Paul A. Yushkevich, Leslie M. Shaw, Jacob G. Dubroff, Parkinson's Progression Markers Initiative, Kenneth Marek, Shirley Lasch, Caroline Tanner, Tanya Simuni, Christopher Coffey, Karl Kieburtz, Renee Wilson, Brit Mollenhauer, Site Investigator, Douglas Galasko, Site Investigator, Tatiana Foroud, Lana Chahine, Andrew Siderowf, John Seibyl, Arthur Toga, Andrew Singleton, Daniel Weintraub, John Trojanowski, Leslie Shaw, Duygu Tosun‐Turgut, Kathleen Poston, Susan Bressman, Kalpana M. Merchant, Werner Poewe, Todd Sherer, Sohini Chowdhury, Mark Frasier, Catherine Kopil, Anna Naito, Vanessa Arnedo, Ray Dorsey, Cynthia Casaceli, Imaging Core, Nichole Daegele, Justin Albani1 Statistics Core, Chelsea Caspell‐Garcia, Liz Uribe, Eric Foster, Jeff Long, Nick Seedorff, Karen Crawford, Danielle Elise Smith, Paola Casalin, Giulia Malferrari, Cheryl Halter, David Russell, Stewart Factor, Penelope Hogarth, David Standaert, Amy Amara, Robert Hauser, Joseph Jankovic, Matthew Stern, Shu‐Ching Hu, Gretchen Todd, Rachel Saunders‐Pullman, Irene Richard, Marie H Saint‐Hilaire, Klaus Seppi, Holly Shill, Hubert Fernandez, Claudia Trenkwalder, Wolfgang Oertel, Daniela Berg, Kathrin Brockman, Isabel Wurster, Liana Rosenthal, Yen Tai, Nicola Pavese, Paolo Barone, Stuart Isaacson, Alberto Espay, Dominic Rowe, Melanie Brandabur, James Tetrud, Grace Liang, Alex Iranzo, Eduardo Tolosa, Karen Marder, Maria de Arriba Sanchez, Leonidis Stefanis, Maria Jose Marti, Javier Ruiz Martinez, Jean‐Christophe Corvol, Jan O Assly, Salima Brillman, Nir Giladi, Debra Smejdir, Julia Pelaggi, Farah Kausar, Linda Rees, Barbara Sommerfield, Madeline Cresswell, Courtney Blair, Karen Williams, Grace Zimmerman, Stephanie Guthrie, Ashlee Rawlins, Leigh Donharl, Christine Hunter, Baochan Tran, Abigail Darin, Carly Linder, Marne Baca, Heli Venkov, Cathi‐Ann Thomas, Raymond James, Beatrice Heim, Paul Deritis, Fabienne Sprenger, Deborah Raymond, Diana Willeke, Zoran Obradov, Jennifer Mule, Nancy Monahan, Katharina Gauss, Deborah Fontaine, Daniel Szpak, Arita McCoy, Becky Dunlop, Laura Marie Payne, Susan Ainscough, Lisbeth Carvajal, Rebecca Silverstein, Kristy Espay, Madelaine Ranola, Elisabet Mondragon Rezola, Helen Mejia Santana, Maria Stamelou, Alicia Garrido, Stephanie Carvalho, Anne Grete Kristiansen, Krista Specketer, Anat Mirlman, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Danna Jennings, Lawrence Slieker, Brian McBride, Colin Watson, Etienne Montagut, Zulfiqar Haider Sheikh, Baris Bingol, Remi Forrat, Pablo Sardi, Tanya Fischer, Alastair D. Reith, Jan Egebjerg, Lone Frydelund Larsen, Nathalie Breysse, Didier Meulien, Barbara Saba, Vera Kiyasova, Chris Min, Thomas McAvoy, Robert Umek, Philip Iredale, Jeremy Edgerton, Susan De Santi, Christian Czech, Frank Boess, Jeffrey Sevigny, Thomas Kremer, Igor Grachev, Kaplana Merchant, Andreja Avbersek, Pierandrea Muglia, Alexandra Stewart, Rene Prashad, Johannes Taucher, Andrew Siderowf, David A. Wolk, Ilya M. Nasrallah +186 morewiley +1 more sourceFrailty and Health Outcomes in People 65 Years or Older Living With Dementia: A Systematic Review of the Literature
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Introduction
Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...Miguel German Borda, Luis Carlos Venegas‐Sanabria, Marco Canevelli, Francesco Landi, Salomón Páez‐García, Kevin O'Hara‐Veintimilla, Lindsay Wallace, Kenneth Rockwood, Tommy Cederholm, Gustavo Duque, Mario Ulises Pérez‐Zepeda, Dag Aarsland +11 morewiley +1 more sourceAreas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE
Epilepsia Open, Volume 11, Issue 1, Page 291-321, February 2026.Abstract Objective
To define and articulate research priorities in epilepsy identified by the European Reference Network for Rare and Complex Epilepsies (ERN EpiCARE), addressing key unmet needs across the spectrum of rare and complex epilepsies. Methods
This position paper was developed through a structured collaborative process involving patient ...Sébile Tchaicha, Stéphane Auvin, Sándor Beniczky, Andreas Brunklaus, Lieven Lagae, Emilio Perucca, Rainer Surges, Sophie Adler, Christoph Helmstaedter, Floor Jansen, Guido Rubboli, Philippe Ryvlin, Nicola Specchio, Eugen Trinka, Ingmar Blümcke, Valentina de Giorgis, Katarzyna Kotulska, Gaetan Lesca, Masa Malenica, Amy McTague, Rima Nabbout, Rikke Steensbjerre Møller, Sandra Silva Arrieta, Isabella Brambilla, Małgorzata Kosla, Kees Braun, J. Helen Cross, Alexis Arzimanoglou +27 morewiley +1 more sourceHeat shock-induced phosphorylation of TAR DNA-binding protein 43 (TDP-43) by MAPK/ERK kinase regulates TDP-43 function [PDF]
, 2017 TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing.Ayala, Yuna M, Bigio, Eileen H, Fey, Erin E, French, Rachel L, Knoverek, Catherine R, Li, Wen, Lin, Binyan, Reeb, Ashley N, Subramanian, Praveen +8 morecore +2 more sourcesEpilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A [PDF]
, 2013 Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe ...Alhusaini, S, Becker, A, Becker, F, Berkovic, SF, Blumcke, I, Buchfelder, M, Buono, RJ, Catarino, CB, Cavalleri, GL, Chaves, J, Coras, R, Costa, PP, da Silva, AM, Dahl, HH, de Graan, PN, Delanty, N, Depondt, C, Doherty, CP, Dorn, T, Duncan, S, Eriksson, KJ, Gruber-Sedlmayr, U, Hakonarson, H, Hallmann, K, Hamer, HM, Hansen, J, Hessel, EV, Hildebrand, MS, Kantanen, AM, Kasperaviciute, D, Kobow, K, Koeleman, BP, Krämer, G, Kunz, WS, Kälviäinen, RK, Leal, B, Lerche, H, Leu, C, Matarin, M, Meng Tan, K, Novy, J, O'Brien, TJ, Pandolfo, M, Paravidino, R, Petrovski, S, Ramasamy, A, Reif, PS, Reinthaler, EM, Robbiano, A, Rosenow, F, Ryten, M, Rössler, K, Scheffer, IE, Schlachter, K, Schoch, S, Silva, BM, Sisodiya, SM, Smith, C, Sperling, MR, Steinhoff, BJ, Stogmann, E, Striano, P, Théâtre, E, Tostevin, A, Trabzuni, D, UK Brain Expression Consortium, The, von Lehe, M, Weale, ME, Weber, Y, Zara, F, Zimprich, F, Zumsteg, D +71 morecore +8 more sourcesNeuropsychiatric symptoms in Alzheimer's disease: Past, present, and future
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract Noncognitive neuropsychiatric symptoms (NPS; e.g., depression, agitation) are nearly universal throughout the course of Alzheimer's disease (AD), cause significant adverse impact to patients and caregivers, and are associated with more rapid progression to severe dementia. Although the importance and presence of NPS was recognized by Dr. Alois Constantine G. Lyketsos, Matthew E. Peters +1 morewiley +1 more source
