Results 61 to 70 of about 240,730 (259)

How Does the Air‐Sea Coupling Frequency Affect Convection During the MJO Passage?

Journal of Advances in Modeling Earth Systems, 2020
The importance of air‐sea coupling in the simulation and prediction of the Madden‐Julian Oscillation (MJO) has been well established. However, it remains unclear how air‐sea coupling modulates the convection and related oceanic features on the subdaily ...
Ning Zhao, Tomoe Nasuno
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The functional role of cross-frequency coupling [PDF]

Trends in Cognitive Sciences, 2010
Recent studies suggest that cross-frequency coupling (CFC) might play a functional role in neuronal computation, communication and learning. In particular, the strength of phase-amplitude CFC differs across brain areas in a task-relevant manner, changes quickly in response to sensory, motor and cognitive events, and correlates with performance in ...
Ryan T, Canolty, Robert T, Knight
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Frequency Measurement of Dynamic Stress in Polarization Maintaining Fibers

IEEE Photonics Journal, 2018
Up to now, the distributed polarization coupling (DPC) measurement system based on white light interferometry (WLI) has been mainly studied for static and quasi-static measurement.
Hongxia Zhang, Yuyao Wang, Guoqiang Wen, Dagong Jia, Tiegen Liu   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Multi-frequency coupled mechanism and propagation characteristics of subsynchronous oscillations induced by IBRs in power systems

International Journal of Electrical Power & Energy Systems
Subsynchronous oscillations induced by inverter-based resources pose a significant threat to power system stability due to their wide propagation. This paper reveals a new propagation phenomenon of subsynchronous oscillations induced by inverter-based ...
Yanhui Xu, Yundan Cheng, Le Zheng
doaj   +1 more source

Coupling of structures using frequency response functions

MATEC Web of Conferences, 2018
In the field of structural dynamics is common to predict the behaviour of a structure regarding structural modifications. In this context, the frequency based substructuring method is well-known to perform structural modifications based on the coupling ...
Silva Tiago, Pereira João
doaj   +1 more source