Results 161 to 170 of about 11,474,340 (357)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A source-differentiated analysis of tropical fresh fruit imports [PDF]

A source-differentiated Almost Ideal Demand System model is used to analyze U.S. demand for the major tropical fresh fruit imports from different countries of origin.
Houston, Jack E., Fonsah, Esendugue Greg, Nzaku, Kilungu   +2 more
core  

Open letter: Six steps towards a national plan of protected horticulture—A call for coordinated action

Plants, People, Planet
The UK's growing reliance on imports and rising climate risks highlight the need to expand protected horticulture as a secure, low‐carbon source of fruit and vegetables.
Sven Batke, David Barker, Darrell Jones, Jack Farmer, Noel O'Leary, Phil Morley, John Walgate, Lee Stiles, Luke Hibberd, Jason Perrott, Alfie Russell, Ralph Weir, Nathanael Dannenberg, Robert Woods, Oliver Green, Stuart Gibson, Laura Pearson, Stephanie Tarvin, David Rowley, Bethan Mcilroy, Su Varma, Paul Rutten, Joe Shepherdson, Kathryn Fletcher, Anthony Paul Sangwine, Helen Sessions, Toni Borella, Samuel Harris, Nathan Thomas, Charlie Guy, Ruth Vichos, Esther deBeer   +31 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

An Empirical Analysis of Market Integration and Efficiency for U.S. Fresh Tomato Markets [PDF]

Fresh tomato trade between the United States and Mexico grew significantly during the 1990s. Moreover, major structural changes in U.S. produce marketing channels increase the complexity of conducting analyses to delineate the impact of liberalized trade.
Padilla-Bernal, Luz E., Thilmany, Dawn D., Loureiro, Maria L.   +2 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

STRATEGIC CHOICES IN PRODUCE MARKETING: ISSUES OF COMPATIBLE USE AND EXCLUSION COSTS [PDF]

Fresh produce suppliers in Europe and the United States use a mix of price and non-price marketing strategies. This paper shows that these strategies create, using Mancur Olson's terms, two collective goods: overall consumer confidence in the market's ...
Sterns, James A., Codron, Jean-Marie, Reardon, Thomas   +2 more
core  

Editorial: Breeding Crops for Enhanced Food Safety

Frontiers in Microbiology, 2022
Maeli Melotto, Wei Zhang, Max Teplitski
doaj   +1 more source