Results 191 to 200 of about 11,474,340 (357)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Enabling Fresh-Produce Availability in Long-Term Care via Hydroponic Green Walls: A Multisite Operational and Cost Evaluation. [PDF]

Nutrients
Freeman S, Zapata SO, Rossnagel E, Panahi A.   +3 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

ANTIMICROBIAL ACTIVITY OF THE CITRON ESSENTIAL OILS AGAINST MICROBIAL PATHOGENS CONTAMINATING FRESH-CUT PRODUCTS

EOs extracted from Citrus medica L. (cv. Liscia-diamante) can be considered a promising strategy to increase the safety of fresh-cut produce accomplishing the consumer's demand addressed to tasty and convenient fresh-cut produce containing only natural ...
Cozzolino Rosaria, Caputo Leonardo, Quintieri Laura, Ricci Ilde, Adduci Angelo, Palumbo Michela, Pace Bernardo, Luparelli Anna, Siano Francesco, Cefola Maria, Schirinzi William   +10 more
core  

Towards IoT-Fog-ML integration for temperature break detection and prediction in fresh produce cold chains: a systematic review and architectural framework. [PDF]

Front Artif Intell
Taguta J, Nturambirwe JFI, Nyirenda CN.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

MODELING FRESH ORGANIC PRODUCE CONSUMPTION: A GENERALIZED DOUBLE-HURDLE MODEL APPROACH [PDF]

Using actual retail data, this study is intended to profile consumers' social economic characteristics related to the growth of the fresh organic produce market with a generalized double-hurdle model.
Huang, Chung L., Lin, Biing-Hwan, Zhang, Feng   +2 more
core  

Sustainable Recovery from Shocks: Policies and Partnerships for Fresh Produce Rescue and Environmental Impact Reduction. [PDF]

Foods
Koutsopoulos MT, Luna-Reyes LF, Bozlak CT, Neff R, Mu T, Romeiko XX, Guo Z, Hosler AS, Pettigrew SM, Pernicka N, Crasto-Donnelly P, Klein A, Feingold BJ.   +12 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source