Results 191 to 200 of about 58,345 (258)

Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA

Angewandte Chemie, EarlyView.
The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio, Michele Ghezzo, Uroš Zavrtanik, Luca Bertini, Valeria Libera, Riccardo Rigo, Jurij Lah, Claudia Sissi   +7 more
wiley   +1 more source

Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics. [PDF]

Signal Transduct Target Ther
Gao Y, Wang Y, Qin Y, Zhang G, Gao S, Chen W, Yang S, Yang X, Tang Y, He Y, Lin Y, Willner I, Tian T, Cai X.   +13 more
europepmc   +1 more source

Catalyst Hide‐and‐Seek Beneath Porous Support Surfaces: Pinpointing Active Site Distribution Through Resonance Energy Transfer

Angewandte Chemie, EarlyView.
Like a shark playing hide‐and‐seek in a coral reef, energy transfer (ET) finds hidden “fish” catalysts in the porous support “reef.” ET allows catalytic species to be precisely mapped, revealing whether they reside near the surface, deep in the pores, or are uniformly distributed. This approach ensures controlled catalyst distribution, highlighting how
Buddhima K. P. Maldeni Kankanamalage, William J. Thompson, Danielle N. Smith, Grace C. Thaggard, Namodhi Wijerathne, Isabella Incognito, Jeffery A. Byers, Jia Niu, Natalia B. Shustova   +8 more
wiley   +1 more source

A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms. [PDF]

PLoS Biol
Mamede LD, Hu M, Vaquer-Alicea J, Titus AR, Passos PM, Lantelme E, French RL, Kirschner PA, Diamond MI, Miller TM, Ayala YM.   +10 more
europepmc   +1 more source

DNA‐Induced Entropic Gain Triggers an Allosteric Switch for Biomolecular Condensation of Heat Shock Transcription Factor 1

Angewandte Chemie, EarlyView.
Hsf1 undergoes phase separation around target DNA, activating stress‐responsive transcription. DNA binding tunes conformational dynamics of Hsf1DBD, which propagates through large‐scale domain rearrangements involving DBD–IDR interactions to regulate phase separation. This hierarchical framework illustrates how local structural events at the side chain
Soichiro Kawagoe, Hiroyuki Kumeta, Tomohide Saio   +2 more
wiley   +1 more source

ABEL-FRET bridges the timescale gap in single-molecule measurements of the structural dynamics in the A_2A adenosine receptor. [PDF]

Commun Chem
Maslov I, Borshchevskiy V, Pérez I, Cherezov V, Hofkens J, Hendrix J, Börsch M, Gensch T.   +7 more
europepmc   +1 more source

Emergence of Chiral Defective Pores Through Chiral Linker Exchange in Nonchiral MOFs for Enantioselective Recognition

Angewandte Chemie, EarlyView.
Chiral recognition remains challenging due to minimal property differences. This work develops chiral defective MOFs via linker exchange to enable rapid, direct, luminescent enantioselective sensing, offering a simple, modular strategy that broadens MOF functionality for portable, low‐cost applications in pharmaceuticals, food safety, and environmental
Zongsu Han, Kun‐Yu Wang, Jiatong Huo, Joshua Rushlow, Zhaoyi Liu, Yihao Yang, Rong‐Ran Liang, Wei Shi, Hong‐Cai Zhou   +8 more
wiley   +1 more source

Real-Time Visualization of Isoform-Specific RAF-KRAS Interactions in Living Cells Using FRET-BRET Hybrid Biosensors. [PDF]

Adv Sci (Weinh)
Go JM, Lee D, Kim M, Han K, Choi G, Song C, Ahn S, Lee Y, Lee J, Wang Y, Suh JS, Yun H, Kim TJ.   +12 more
europepmc   +1 more source

Color‐Pure Organic Luminophores: Characteristics, Definitions, Physical Basis and Fundamental Design Principles

Angewandte Chemie, EarlyView.
Color‐pure all‐organic emitters, i.e., with narrow spectral characteristics, are intensively studied for high‐definition organic LEDs and multi‐color bioimaging. In order to guide targeted materials design, this educative review discusses spectral characteristics, proper definitions and units, and the physical basis of spectral broadening, to distill ...
Johannes Gierschner, Sunwu Song, Siyang Feng, Liangxuan Wang, Miguel Ródenas, Begoña Milián‐Medina, Min Sang Kwon   +6 more
wiley   +1 more source

A Single Dimer of the SARS-CoV‑2 N Protein Can Associate with Multiple Fragments of Single-Stranded and Stem-Loop RNA: A Single-Molecule FRET and FCS Investigation. [PDF]

ACS Omega
Kaneda N, Suzuki L, Endo S, Husna SMA, Ishikawa S, Takahashi H, Oikawa H, Itoh Y, Takahashi S.   +8 more
europepmc   +1 more source