Results 1 to 10 of about 56,649 (315)
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling [PDF]
Nature Communications, 2016 PDZ domain-containing proteins are known to function as intracellular scaffolds. Here, Egea-Jimenez et al. report the structure of the tandem PDZ domains of syntenin in complex with a Frizzled 7 peptide and PIP2, show that the ligands bind to syntenin ...
Antonio Luis Egea-Jimenez +9 more
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Non-Coding RNA and Frizzled Receptors in Cancer
Frontiers in Molecular Biosciences, 2021 Frizzled receptors have been long recognized for their role in Wnt/β-catenin signaling, a pathway known for its tumorigenic effects. More recent studies of frizzled receptors include efforts to understand non-coding RNA (ncRNA) regulation of these ...
Alex J. Smith +3 more
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Fluids and Barriers of the CNS, 2021 Background Destruction of blood–brain barrier (BBB) is one of the main mechanisms of secondary brain injury following intracerebral hemorrhage (ICH).
Wei He +7 more
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eLife, 2019 Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6.
Yuyong Tao +14 more
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Toxins, 2020 Toxin B (TcdB) produced by Clostridioides difficile is a main pathogenicity factor that affects a variety of different cell types within the colonic mucosa. TcdB is known to utilize frizzled-1,2,7 and chondroitin sulfate proteoglycan-4 (CSPG4) as protein
Daniel Henkel +5 more
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Developmental Cell, 2004 The Wnt signaling network is arguably one of the most complex molecular modules by which cells communicate. Though we become accustomed to novel components, the discovery of an unexpected Wnt receptor ligand, Norrin, is surprising even to the connoisseur.
Christof Niehrs
openalex +4 more sources
Deregulation of Frizzled Receptors in Hepatocellular Carcinoma [PDF]
International Journal of Molecular Sciences, 2018 G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a “cancer driver”. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer ...
Kristy Kwan-Shuen Chan, R. Lo
semanticscholar +4 more sources
Frizzled Receptors in Development and Disease. [PDF]
Current Topics in Developmental Biology, 2016 Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr, Vangl, and a small number of additional membrane and membrane-associated proteins, they also play a central role in tissue polarity/planar cell polarity (PCP) signaling ...
Yanshu Wang +3 more
semanticscholar +4 more sources
Structural Basis of Wnt Recognition by Frizzled [PDF]
Science, 2012 Dissecting Wnt/Fz Interaction Wnt proteins activate the transmembrane receptor Frizzled (Fz) to initiate pathways central to vertebrate and invertebrate development. Wnts are palmitoylated, which has complicated structural and functional characterization. Janda et al.
C. Y. Janda +4 more
semanticscholar +3 more sources
Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway [PDF]
Communications BiologyAdult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling ...
Pengfei Du +7 more
doaj +2 more sources