Results 91 to 100 of about 56,649 (315)
Journal of Biological Chemistry, 2018 Upon binding to the canonical WNT glycoproteins, Frizzled family receptors (FZDs) and low-density lipoprotein receptor-related protein 5/6 (LRP5/6) undergo a series of polymerizations on the cell surface that elicit canonical WNT/β-catenin signaling. The
Y. Hua +6 more
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Cardiac Hypertrophy and the Wnt/Frizzled Pathway [PDF]
Hypertension, 2007 The heart responds to sustained pressure overload with hypertrophy. Although at first glance this seems to be an adaptive mechanism by which the heart battles against increased workload, there is evidence that these “compensatory changes,” even early in the game, are different from the benign, truly adaptive response that occurs, for example, in ...
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Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway [PDF]
Cell, 1998 We investigated the potential of double-stranded RNA to interfere with the function of genes in Drosophila. Injection of dsRNA into embryos resulted in potent and specific interference of several genes that were tested. In contrast, single-stranded RNA weakly interfered with gene activity. The method was used to determine the reception mechanism of the
Jason R. Kennerdell, Richard W. Carthew
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Chemistry–Methods, EarlyView.Multilayered sandwich‐structured MXene/pristine carbon/biomass cellulose composite films have been constructed with a hierarchical network architecture. A symmetric flexible soft‐pack supercapacitor fabricated by using the film retains 98% of its initial capacitance after 10 000 cycles.
Lina Liu +7 more
wiley +1 more source
Role of the
Neural Development, 2009 Background The Wnt signaling pathway regulates several fundamental developmental processes and recently has been shown to be involved in different aspects of synaptic differentiation and plasticity.
Alvarez Alejandra R +4 more
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Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
The FASEB Journal, 2017 Signaling pathway modules are often encoded by several closely related paralogous genes that can have redundant roles and are therefore difficult to analyze by loss‐of‐function analysis. A typical example is the Wnt signaling pathway, which in mammals is
O. Voloshanenko +4 more
semanticscholar +1 more source
Developmental Dynamics, EarlyView.Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters +5 more
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The pathological role of Wnt5a in psoriasis and psoriatic arthritis. [PDF]
, 2019 Psoriasis (PsO) is a chronic inflammatory skin disease with both local and systemic components. PsO-associated arthritis, known as psoriatic arthritis (PsA), develops in approximately 13%-25% of PsO patients.
Li, Zhengxiao +2 more
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Cukurova Medical Journal, 2021 Amaç: Bu çalışmada blastik fazda farklı hücre serilerinde tutulum gösteren iki farklı Ph (+) kronik miyeloid lösemi (KML) hücre hattında, Wnt sinyal yolağı ana oyuncuları olan Wnt ve Frizzled genlerinin ifade farklılıklarının incelenmesi amaçlanmıştır ...
Hakkı Ogün Sercan, Melek Pehlivan
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Developmental Dynamics, EarlyView.Abstract Background Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline morphogenesis in non‐amniotes can occur without mitosis, through Planar Cell Polarity (PCP) signaling. By contrast, amniotes utilize both cellular processes for developing the early midline landmark, the primitive streak (PS).
Zhiling Zhao, Rieko Asai, Takashi Mikawa
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