Results 101 to 110 of about 56,649 (315)

Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon [PDF]

, 2012
The anterior commissure forms the first axon connections between the two sides of the embryonic telencephalon. We investigated the role of the transmembrane receptor Frizzled-3a in the development of this commissure using zebrafish as an experimental ...
Abramoff, Akimenko, Armstrong, Barresi, Bhanot, Brian Key, Briancon-Marjollet, Carron, Chitnis, Christine A. Devine, Ciruna, Danesin, Dann, Devine, Falk, Fazeli, Fjose, Frohman, Gerety, Hjorth, Hjorth, Houart, Hutson, Hutson, Joseph A. Rothnagel, Kassai, Kawahara, Krauss, Krauss, Kullander, Lauderdale, Lindwall, Lyuksyutova, Miyasaka, Molven, Nona, Robu, Ross, Serafini, Sheldahl, Slusarski, Slusarski, Strähle, Suto, Turner, Wada, Wang, Wang, Wang, Widelitz, Wilson, Wolfgang Hofmeister, Xiao, Zhou   +53 more
core   +1 more source

Wnt signaling: A complex issue

Biological Research, 2002
The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification.
BART HENDRIKS, ERNST REICHMANN
doaj  

The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. [PDF]

PLoS Genetics, 2015
Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5.
Naomi Levy-Strumpf, Meghan Krizus, Hong Zheng, Louise Brown, Joseph G Culotti   +4 more
doaj   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]

, 2017
Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas, Buschman, Matthew D, Dunkel, Ying, Ear, Jason, Ghosh, Pradipta, Sun, Nina   +5 more
core   +2 more sources

Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants

Stem Cells International, 2016
The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors.
Katharina Nothelfer, Florian Obermayr, Nadine Belz, Ellen Reinartz, Petra M. Bareiss, Hans-Jörg Bühring, Rudi Beschorner, Lothar Just   +7 more
doaj   +1 more source

Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development

The International Journal of Developmental Biology, 2004
Recent studies indicate a role for Wnt signaling in regulating lens cell differentiation (Stump et al., 2003). Here we investigated expression patterns of Wnt receptors, the Frizzleds (Fzs) and the Wnt signaling regulators, the secreted frizzled-related proteins (Sfrps), during rodent lens development.
Yongjuan Chen, John W. McAvoy, Frank J. Lovicu, R.J.W. Stump   +3 more
openaire   +4 more sources

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]

, 2016
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja, Lechpammer, Mirna, Pećina-Šlaus, Nives   +2 more
core   +2 more sources

LINC00922: A Critical Oncogenic Long Non‐Coding RNA Involved in Cancer Progression, Chemotherapy Resistance, and microRNA Regulation

Medicine Advances, EarlyView.
LINC00922 is located at 16q21 and is primarily expressed in the cytoplasm. It has been implicated in promoting tumor progression, contributing to poor overall survival (OS) and disease‐free survival (DFS) in patients. LINC00922 drives cancer progression through a complex network of gene interactions, enhances chemotherapy resistance in cancer cells ...
Jiahua Si, Chenhao Liang, Xueting Zhang, Hening Xu, Xinming Su, Luqing Liu, Ruyi Yuan, Yuemin Ding, Shiwei Duan   +8 more
wiley   +1 more source