Results 111 to 120 of about 51,161 (270)

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
core   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

Wnt signaling during tooth replacement in zebrafish (Danio rerio) : pitfalls and perspectives [PDF]

, 2014
The canonical (13-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions.
Elderweirdt, Fien, Huysseune, Ann, Soenens, Mieke   +2 more
core   +3 more sources

Phenotypic patterns of metabolic dysfunction‐associated steatotic liver disease in type 2 diabetes: The impact of insulin

European Journal of Clinical Investigation, EarlyView.
Abstract Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) often leads to hepatic insulin resistance (IR), yet its link to liver‐specific insulin‐mediated glucose uptake (IGLU) in type 2 diabetes (T2D) remains unclear. We aimed to explore this MASLD‐T2D relationship, addressing organ‐specific IR for personalized management and
Queralt Martín‐Saladich, Rafael Simó, Andreea Ciudin, Julia Baguña, Clara Ramirez‐Serra, Santiago Aguadé‐Bruix, Albert Roque, Maria N. Pizzi, Hug Cuéllar, Nuria Roson‐Gradaille, Miguel A. González Ballester, Juan M. Pericàs, José Raul Herance   +12 more
wiley   +1 more source

EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. [PDF]

, 2019
Wnt signalling drives many processes in development, homeostasis and disease; however, the role and mechanism of individual ligand-receptor (Wnt-Frizzled (Fzd)) interactions in specific biological processes remain poorly understood. Wnt9a is specifically
Barahona, Rocio, Carrillo-Terrazas, Marvic, Drummond, Iain A, Gonzalez, David, Grainger, Stephanie, Houston, Jack, Kamei, Caramai N, Lonquich, Brianna, Nguyen, Nicole, Oon, Chet Huan, Richter, Jenna, Setayesh, Jordan, Traver, David, Willert, Karl, Wozniak, Jacob M   +14 more
core  

Osteochondrosis in horses: An overview of genetic and other factors

Equine Veterinary Journal, EarlyView.
Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez, Pablo J. Marín‐García, M. Lola Llobat   +2 more
wiley   +1 more source

Physical and functional interactions between LDLR family members and CXCR4 in breast cancer

The FEBS Journal, EarlyView.
Here, we demonstrate that members of the low‐density lipoprotein receptor (LDLR) family can regulate C‐X‐C chemokine receptor type 4 (CXCR4) signaling and therefore affect CXCR4‐induced breast cancer metastasis. We found that very low‐density lipoprotein receptor (VLDLR), low‐density lipoprotein receptor‐related protein 8 (LRP8) and apolipoprotein E ...
Jiankang Zhang, Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Dan‐ni Ren, Weidong Zhu   +7 more
wiley   +1 more source

Wnt Signaling Alteration in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Mice: Special Focus on Frizzled-5 Cellular Expression Pattern.

PLoS ONE, 2016
BackgroundAmyotrophic lateral sclerosis is a chronic neurodegenerative disease characterized by progressive paralysis due to degeneration of motor neurons by unknown causes.
Carlos González-Fernández, Renzo Mancuso, Jaume Del Valle, Xavier Navarro, Francisco Javier Rodríguez   +4 more
doaj   +1 more source

Epigenetic control of cell identities from epiblast to gastrulation

The FEBS Journal, EarlyView.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

Xenopus frizzled-5: a frizzled family member expressed exclusively in the neural retina of the developing eye

Mechanisms of Development, 2001
We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia.
Saulius Sumanas, Stephen C. Ekker
openaire   +3 more sources