Results 111 to 120 of about 56,649 (315)

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Tris(1,3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos. [PDF]

, 2017
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a high-production volume organophosphate flame retardant widely used within the United States. Within zebrafish, initiation of TDCIPP exposure at 0.75 h post-fertilization (hpf) results in genome-wide ...
Altomare, Diego, Dasgupta, Subham, Kupsco, Allison, Leet, Jessica K, Vliet, Sara M, Volz, David C   +5 more
core   +3 more sources

The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling

eLife, 2017
The non-canonical Wnt/Ca2+ signaling pathway plays important roles in embryonic development, tissue formation and diseases. However, it is unclear how the Wnt ligand-stimulated, G protein-coupled receptor Frizzled activates phospholipases for calcium ...
Bo Gong, Weimin Shen, Wanghua Xiao, Yaping Meng, Anming Meng, Shunji Jia   +5 more
doaj   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation [PDF]

, 2006
The planar cell polarity (PCP) pathway is conserved throughout evolution, but it mediates distinct developmental processes. In Drosophila, members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the
Brinkman, Brendan C., Chen, Ping, Dickinson, Mary E., Fraser, Scott E., Hamblet, Natasha S., Mark, Sharayne, Segil, Neil, Wallingford, John B., Wang, Jianbo, Wynshaw-Boris, Anthony   +9 more
core   +1 more source

Two Wnts Instruct Topographic Synaptic Innervation in C. elegans

Cell Reports, 2013
Gradients of topographic cues play essential roles in the organization of sensory systems by guiding axonal growth cones. Little is known about whether there are additional mechanisms for precise topographic mapping of synaptic connections. Whereas the C.
Kota Mizumoto, Kang Shen
doaj   +1 more source

Comprehensive Analysis of the Expression and Prognosis for in Breast Carcinoma

Cell Transplantation, 2020
Secreted frizzled-related proteins ( SFRPs ) are a group of five secreted glycoproteins— SFRP1 , SFRP2 , SFRP3 (frizzled related protein , FRZB ), SFRP4 , and SFRP5 —which contain a frizzled-related cysteine-rich domain and a netrin module.
Zeng-Hong Wu, You-jing Zhang, Jian-Xin Yue, Tao Zhou   +3 more
doaj   +1 more source

Targeted alveolar regeneration with Frizzled-specific agonists

Cell, 2023
Ahmad N. Nabhan, J. Webster, Jarrett J. Adams, Levi L Blazer, C. Everrett, Celine Eidenschenk, Alexander Arlantico, I. Fleming, H. Brightbill, P. Wolters, Z. Modrusan, S. Seshagiri, S. Angers, S. Sidhu, K. Newton, J. Arron, V. Dixit   +16 more
semanticscholar   +1 more source

Documenting den characteristics of bears and wolves in the Greater Yellowstone Ecosystem using LIDAR technology

Wildlife Society Bulletin, EarlyView.
Previous studies have documented den site characteristics through physical measurements recorded by researchers in the field. Using the light detection and ranging (LiDAR) sensor onboard an Apple iPad Pro, we scanned the interior of black and grizzly bear dens (n = 9) located in the Greater Yellowstone Ecosystem (GYE) to generate point clouds of den ...
Tyler J. Brasington, Jessica M. Hadley, Justin K. Schwabedissen, John A. Stephenson   +3 more
wiley   +1 more source

Cell-type specific potent Wnt signaling blockade by bispecific antibody. [PDF]

, 2018
Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for therapeutic development.
Bidlingmaier, Scott, Ha, Kevin D, Lee, Nam-Kyung, Liu, Bin, Sherbenou, Daniel W, Su, Yang, Zhang, Yafeng   +6 more
core   +2 more sources