Results 121 to 130 of about 56,649 (315)

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

Aging Cell, EarlyView.
Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targets collagen remodeling and stem cell function‐related genes.
Toby L. Chambers, Jaden Wells, Pieter Jan Koopmans, Francielly Morena, Zain B. Malik, Nicholas P. Greene, Antonio Filareto, Michael Franti, Patrizia Sini, Harald Weinstabl, Robert T. Brooke, Milda Milčiūtė, Juozas Gordevičius, Steve Horvath, Yuan Wen, Cory M. Dungan, Kevin A. Murach   +16 more
wiley   +1 more source

Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]

, 2010
Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Dandekar, D., De Gendt, K., Hu, Z., O'Shaughnessy, P.J., Verhoeven, G., Wilkinson, M.F.   +5 more
core   +2 more sources

BRAIDing receptors for cell-specific targeting

eLife
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity.
Hui Chen, Sung-Jin Lee, Ryan Li, Asmiti Sura, Nicholas Suen, Archana Dilip, Yan Pomogov, Meghah Vuppalapaty, Timothy T Suen, Chenggang Lu, Yorick Post, Yang Li   +11 more
doaj   +1 more source

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

Genes & Development, 2017
Here, DeBruine et al. report the crystal structure of the Wnt ligand Frizzled (FZD) receptor cysteine-rich domains (CRDs) in complex with palmitoleic acid, which reveals a CRD tetramer consisting of two cross-braced CRD dimers.
Z. DeBruine, J. Ke, K. Harikumar, X. Gu, Peter Borowsky, B. Williams, Wenqing Xu, L. Miller, H. Xu, K. Melcher   +9 more
semanticscholar   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Forced expression of Wnt antagonists sFRP1 and WIF1 sensitizes chronic myeloid leukemia cells to tyrosine kinase inhibitors

Tumor Biology, 2017
Chronic myeloid leukemia is a clonal myeloproliferative disorder that arises from the neoplastic transformation of the hematopoietic stem cell, in which the Wnt/β-catenin signaling pathway has been demonstrated to play an important role in disease ...
Melek Pehlivan, Ceyda Caliskan, Zeynep Yuce, Hakkı Ogun Sercan   +3 more
doaj   +1 more source

MicroRNA-96-5p Facilitates the Viability, Migration, and Invasion and Suppresses the Apoptosis of Cervical Cancer Cells byNegatively Modulating SFRP4

Technology in Cancer Research & Treatment, 2020
Purpose: The current study was intended to research the functional role and regulatory mechanism of microRNA-96-5p in the progression of cervical cancer. Methods: MicroRNA-96-5p expression in cervical cancer tissues was assessed by quantitative real-time
Huiling Zhang MM, Ruxin Chen MM, Jinyan Shao BM   +2 more
doaj   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer

Journal of Pathology, 2016
Frizzled receptors mediate Wnt ligand signalling, which is crucially involved in regulating tissue development and differentiation, and is often deregulated in cancer.
G. Corda, G. Sala, R. Lattanzio, M. Iezzi, M. Sallese, Giorgia Fragassi, A. Lamolinara, H. Mirza, D. Barcaroli, Sibylle Ermler, Elisabete Silva, Hemad Yasaei, R. Newbold, P. Vagnarelli, M. Mottolese, P. Natali, L. Perracchio, J. Quist, A. Grigoriadis, P. Marra, A. Tutt, M. Piantelli, S. Iacobelli, V. de Laurenzi, A. Sala   +24 more
semanticscholar   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source