Results 121 to 130 of about 53,326 (285)

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Remote activation of the Wnt/β-catenin signalling pathway using functionalised magnetic particles.

PLoS ONE, 2015
Wnt signalling pathways play crucial roles in developmental biology, stem cell fate and tissue patterning and have become an attractive therapeutic target in the fields of tissue engineering and regenerative medicine.
Michael Rotherham, Alicia J El Haj
doaj   +1 more source

Retraction: LncRNA AWPPH promotes the growth of triple-negative breast cancer by up-regulating frizzled homolog 7 (FZD7) [PDF]

, 2022

openalex   +1 more source

Placental Protein Release and Uptake From the Fetal Circulation in Healthy Term Pregnancies—A Human In Vivo Exploratory Study

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Fetal‐placental communication was explored by comparing protein abundances in paired umbilical artery and vein samples, using the SomaLogic 5000‐plex platform. 766 proteins were identified as released by the placenta, largely supported by placental gene expression patterns reported in transcriptomic studies.
Hilde Bastøe Sellevoll, Ina Jungersen Andresen, Ane Cecilie Westerberg, Maren‐Helene Langeland Degnes, Thor Ueland, Manuela Zucknick, Trond Melbye Michelsen   +6 more
wiley   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, Volume 13, Issue 7, 3 February 2026.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Non‐conventional Frizzled ligands and Wnt receptors [PDF]

, 2008
Marijke Hendrickx, Luc Leyns
openalex   +1 more source

USAG‐1 and Regenerative Dentistry, Therapeutic Implications and Future Directions: Review of the Literature

Clinical and Experimental Dental Research, Volume 12, Issue 1, February 2026.
ABSTRACT Objectives Uterine Sensitization‐Associated Gene 1 (USAG‐1) is a bone morphogenetic protein (BMP) antagonist vital for tooth regeneration that is expressed in kidney, gingiva, and dental tissues. Material and methods We analyzed recent studies focusing on USAG‐1 and its involvement in BMP and Wnt signaling pathways related to dental tissue ...
Zahra Moradi, Mohammadreza Karimi, Shirin Kolahdouz, Narges Arya, Vahid Akheshteh, Fatemeh Ayanzadeh, Yasmina Aalizadeh, Hanieh Moravvej, Marzie Keshavarzi, Amar Basri   +9 more
wiley   +1 more source

Multiple Wnts and Frizzled Receptors Regulate Anteriorly Directed Cell and Growth Cone Migrations in Caenorhabditis elegans [PDF]

, 2006
Chun‐Liang Pan, James Endres Howell, Scott G. Clark, Massimo A. Hilliard, Shaun Cordes, Cornelia I. Bargmann, Gian Garriga   +6 more
openalex   +1 more source

Characterisation of Embryonic Dermal Precursor Cells [PDF]

, 2018
Skin is an attractive organ for the acquisition of stem cells due to its accessibility, size and potential for autologous transplants. Research into skin development has implications for the isolation of stem cell populations, for example skin-derived ...
BLINCKO, SARAH
core  

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng   +6 more
wiley   +1 more source