Results 131 to 140 of about 56,649 (315)
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. [PDF]
, 2007 Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt signaling and thus inhibits osteogenesis.
Angela Smolarz +9 more
core +3 more sources
Discovery of novel frizzled-7 inhibitors by targeting the receptor’s transmembrane domain
OncoTarget, 2017 Frizzled (Fzd) proteins are seven transmembrane receptors that belong to a novel and separated family of G-protein-coupled receptors (GPCRs). The Fzd receptors can respond to Wnt proteins to activate the canonical β-catenin pathway which is important for
Wei Zhang +4 more
semanticscholar +1 more source
European Journal of Clinical Investigation, EarlyView.Abstract Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) often leads to hepatic insulin resistance (IR), yet its link to liver‐specific insulin‐mediated glucose uptake (IGLU) in type 2 diabetes (T2D) remains unclear. We aimed to explore this MASLD‐T2D relationship, addressing organ‐specific IR for personalized management and
Queralt Martín‐Saladich +12 more
wiley +1 more source
, 2019 Planar cell polarity (PCP), the coherent in-plane polarization of a tissue on multicellular length scales, provides directional information that guides a multitude of developmental processes at cellular and tissue levels.
Mani, Madhav, Shadkhoo, Shahriar
core +1 more source
Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis [PDF]
, 2010 Wnt signaling has been implicated in somite, limb, and branchial arch myogenesis but the mechanisms and roles are not clear. We now show that Wnt signaling via Lef1 acts to regulate the number of premyogenic cells in somites but does not regulate ...
Ai +54 more
core +1 more source
Frizzled-1 receptor regulates adult hippocampal neurogenesis
Molecular Brain, 2016 BackgroundIn the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus.
Muriel D Mardones +8 more
semanticscholar +1 more source
Osteochondrosis in horses: An overview of genetic and other factors
Equine Veterinary Journal, EarlyView.Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez +2 more
wiley +1 more source
Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]
, 2013 Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y +6 more
core +1 more source
PLoS ONE, 2016 BackgroundAmyotrophic lateral sclerosis is a chronic neurodegenerative disease characterized by progressive paralysis due to degeneration of motor neurons by unknown causes.
Carlos González-Fernández +4 more
doaj +1 more source
MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8
OncoTarget, 2016 microRNAs are aberrantly expressed during the development and progression of a variety of human cancers, including colorectal cancer (CRC). Of these microRNAs, microRNA-375 (miR-375) was previously observed to be downregulated in human colorectal cancer ...
Ling-ling Xu +7 more
semanticscholar +1 more source