Results 131 to 140 of about 51,161 (270)
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, Volume 45, Issue 5, Page 1307-1322, September 2025.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. [PDF]
, 2019 Heterogeneous prostatic carcinoma-associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT).
Agarwal, Priyanka +14 more
core +1 more source
Wingless Capture by Frizzled and Frizzled2 in Drosophila Embryos
Developmental Biology, 2001 A variety of factors could influence how far developmental signals spread. For example, the Patched receptor limits the range of its ligand Hedgehog. Somehow, the Frizzled2 receptor has the opposite effect on its ligand. Increasing the level of Frizzled2 stabilizes Wingless and thus extends the Wingless gradient in Drosophila wing imaginal disks.
Lecourtois, Magalie +3 more
openaire +4 more sources
The Journal of Pathology, Volume 267, Issue 1, Page 10-24, September 2025.Abstract The origin of mucinous cystic neoplasms (MCNs) remains a major challenge in hepato‐pancreato‐biliary pathology. These cystic tumors are defined by their mucinous epithelium and ovarian‐like stroma, with an estimated 10% risk of progression to invasive carcinoma. The origin of the ovarian‐like stroma remains a subject of debate.
Zoe Leoni +20 more
wiley +1 more source
A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A [PDF]
, 1997 Xi He +5 more
openalex +1 more source
GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger
British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng +3 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, Volume 19, Issue 8, Page 2174-2195, August 2025.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
International Journal of Cancer, Volume 157, Issue 3, Page 559-572, 1 August 2025.What's new? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song +10 more
wiley +1 more source
Disruption of the Non-Canonical WNT Pathway in Lung Squamous Cell Carcinoma
Clinical Medicine Insights: Oncology, 2008 Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway.
Eric H.L. Lee +9 more
doaj +1 more source
Pathway Specificity by the Bifunctional Receptor Frizzled Is Determined by Affinity for Wingless [PDF]
, 2000 E RULIFSON
openalex +1 more source