Results 141 to 150 of about 51,161 (270)
Osteoarthritis: Mechanisms and Therapeutic Advances
MedComm, Volume 6, Issue 8, August 2025.A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu +3 more
wiley +1 more source
Structure and expression of a novel frizzled gene isolated from the developing mouse gut [PDF]
, 2000 Talat H. Malik, Ramesh A. Shivdasani
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Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.Effect of lobaric acid on Wnt/β‐catenin pathway in breast cancer. ABSTRACT Lichen secondary metabolites with many remarkable biological activities are used in cancer treatments due to their low side effects and high anticancer potential. In particular, these metabolites constitute an interesting research area in cancer treatments due to their potential
Şeyda Nur Kalın +6 more
wiley +1 more source
Journal of Coloproctology, 2015 Colorectal cancer is linked to several signaling pathways such as Wnt pathway. Our objective is to detect and verify the integrity of protein members of Wnt signaling pathway in colorectal carcinoma and non-neoplastic colorectal tissue.
Rodrigo Felippe Ramos +5 more
doaj
Progress in the development of modulators targeting Frizzleds
Pharmacological ResearchThe Frizzleds (FZDs) receptors on the cell surface belong to the class F of G protein-coupled receptors (GPCRs) which are the major receptors of WNT protein that mediates the classical WNT signaling pathway and other non-classical pathways. Besides, the FZDs also play a core role in tissue regeneration and tumor occurrence.
Junlan Chuan +5 more
openaire +3 more sources
Photophagy: Unveiling a Novel Cellular Mechanism in UVB‐Induced Skin Aging and Resilience
International Journal of Dermatology, EarlyView.
Sheikh A. Umar, Sheikh A. Tasduq
wiley +1 more source
Journal of Diabetes Investigation, Volume 16, Issue 8, Page 1430-1444, August 2025.Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang +5 more
wiley +1 more source
ChemMedChem, Volume 20, Issue 14, July 18, 2025.ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone +17 more
wiley +1 more source
The maternal Xenopusβ‐catenin signaling pathway, activated by frizzled homologs, induces goosecoid in a cell non‐autonomous manner [PDF]
, 2000 Jeffrey D. Brown +4 more
openalex +1 more source
Molecular structure of frizzled, a Drosophila tissue polarity gene.
, 1990 Paul N. Adler +4 more
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