Results 141 to 150 of about 53,326 (285)

Microtubule Inhibitors Induce Cross‐Resistance to Osimertinib Through CaMKII Activation in EGFR‐Mutated NSCLC

Cancer Science, Volume 117, Issue 2, Page 418-428, February 2026.
Eighteen‐week treatment with microtubule inhibitors induces resistance to osimertinib in EGFR‐mutated NSCLC cells. Vinorelbine‐ and paclitaxel‐resistant cells showed activation of FZD7 and CaMKII and increased sensitivity to CaMKII inhibition, with additive or synergistic effects when combined with osimertinib.
Kento Kono, Ryosuke Tanino, Yukari Tsubata, Eshat Fahmida Haque, Takeshi Isobe, Tamio Okimoto   +5 more
wiley   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Modification of Keratin Integrations and the Associated Morphogenesis in Frizzling Chicken Feathers [PDF]

Hao Wu, Tsao‐Chi Chuang, Wan-Chi Liao, Kai-Jung Chi, Hsu‐Chen Cheng, Wen‐Tau Juan   +5 more
openalex   +3 more sources

Editor's evaluation: Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

, 2021
Makoto Sato
openalex   +1 more source

Wnt signaling enhances the capacity of cochlear Frizzled 10-positive glial cells as neural stem cells [PDF]

, 2023
Man Wang, Lei Xu, Yuechen Han, Xue Wang, Junze Lu, Fang Chen, Zhiqun Yao, Yu Meng, Yan Li, Yanqing Wang, Jingxin Li, Chunjie Zhao, Renjie Chai, Wenwen Liu, Haibo Wang   +14 more
openalex   +1 more source

Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio

Journal of the Pakistan Medical Association
The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family ...
Sana Akhlaq, Saba Khaliq
doaj   +1 more source

Secreted Frizzled-Related Protein 5 Ameliorates Vascular Calcification in a Rat Model of Chronic Kidney Disease through the Wnt/β-Catenin Pathway [PDF]

, 2021
Dai Deng, Xue Han, Zongli Diao, Wenhu Liu   +3 more
openalex   +1 more source

FZD6 (Frizzled class receptor 6) [PDF]

, 2019
Alessandro Beghini, Giovanni Postorino
openalex   +1 more source

X-Ray Diffraction data from Frizzled-8 complex with designed Wnt agonist, source of 5UN6 structure

, 2017
Kevin M. Jude
openalex   +1 more source

The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity [PDF]

, 2015
Genevieve Abbruzzese, Anne‐Kathrin Gorny, Lilian Kaufmann, Hélène Cousin, Iivari Kleino, Herbert Steinbeißer, Dominique Alfandari   +6 more
openalex   +1 more source