Physical and functional interactions between LDLR family members and CXCR4 in breast cancer
The FEBS Journal, EarlyView.Here, we demonstrate that members of the low‐density lipoprotein receptor (LDLR) family can regulate C‐X‐C chemokine receptor type 4 (CXCR4) signaling and therefore affect CXCR4‐induced breast cancer metastasis. We found that very low‐density lipoprotein receptor (VLDLR), low‐density lipoprotein receptor‐related protein 8 (LRP8) and apolipoprotein E ...
Jiankang Zhang +7 more
wiley +1 more source
Mechanisms of Development, 2001 We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia.
Saulius Sumanas, Stephen C. Ekker
openaire +3 more sources
Epigenetic control of cell identities from epiblast to gastrulation
The FEBS Journal, EarlyView.In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley +1 more source
EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. [PDF]
, 2019 Wnt signalling drives many processes in development, homeostasis and disease; however, the role and mechanism of individual ligand-receptor (Wnt-Frizzled (Fzd)) interactions in specific biological processes remain poorly understood. Wnt9a is specifically
Barahona, Rocio +14 more
core
BMC Evolutionary Biology, 2019 Background Frizzled family members belong to G-protein coupled receptors and encode proteins accountable for cell signal transduction, cell proliferation and cell death. Members of Frizzled receptor family are considered to have critical roles in causing
Suman Seemab +5 more
doaj +1 more source
WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution
The FEBS Journal, EarlyView.WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert +16 more
wiley +1 more source
A novel deletion in KRT75L4 and KRT75 mediating the frizzle trait in an Indonesian frizzle chicken [PDF]
AIP Conference Proceedings, 2021 Sayli Salsabila +9 more
openaire +2 more sources
Remote activation of the Wnt/β-catenin signalling pathway using functionalised magnetic particles.
PLoS ONE, 2015 Wnt signalling pathways play crucial roles in developmental biology, stem cell fate and tissue patterning and have become an attractive therapeutic target in the fields of tissue engineering and regenerative medicine.
Michael Rotherham, Alicia J El Haj
doaj +1 more source
The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases [PDF]
, 1998 Yu Katherine Xu, Roel Nusse
openalex +1 more source
Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains
Journal of Biological Chemistry, 2017 Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically involves the binding of a Wnt protein to the cysteine-rich domain (CRD) of a Frizzled receptor. Wnt-Frizzled interactions can be
Mark Agostino, S. Pohl, A. Dharmarajan
semanticscholar +1 more source