Results 11 to 20 of about 51,161 (270)

Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling [PDF]

Nature Communications, 2016
PDZ domain-containing proteins are known to function as intracellular scaffolds. Here, Egea-Jimenez et al. report the structure of the tandem PDZ domains of syntenin in complex with a Frizzled 7 peptide and PIP2, show that the ligands bind to syntenin ...
Antonio Luis Egea-Jimenez, Rodrigo Gallardo, Abel Garcia-Pino, Ylva Ivarsson, Anna Maria Wawrzyniak, Rudra Kashyap, Remy Loris, Joost Schymkowitz, Frederic Rousseau, Pascale Zimmermann   +9 more
doaj   +7 more sources

Phosphorylation of Frizzled-3 [PDF]

Journal of Biological Chemistry, 2006
Wnts are secreted proteins important to many biological processes. frizzled genes encode a family of Wnt receptors that signal to the intracellular compartment through the cytosolic protein Disheveled. Limited information is available concerning the regulation of Frizzleds at a biochemical level. We report here that Xenopus Frizzled-3 is phosphorylated
Robert J. Fagan, Peter S. Klein, Wang A. Yanfeng, Change Tan   +3 more
openaire   +3 more sources

Frizzled‐4 is required for normal bone acquisition despite compensation by Frizzled‐8 [PDF]

Journal of Cellular Physiology, 2020
AbstractThe activation of the Wnt/β‐catenin signaling pathway is critical for skeletal development but surprisingly little is known about the requirements for the specific frizzled (Fzd) receptors that recognize Wnt ligands. To define the contributions of individual Fzd proteins to osteoblast function, we profiled the expression of all 10 mammalian ...
Bart O. Williams, Megan N. Michalski, Soohyun P. Kim, Priyanka Kushwaha, Gabrielle E. Foxa, Ryan C. Riddle, Ryan C. Riddle, Ryan E. Tomlinson   +7 more
openaire   +3 more sources

Comprehensive analysis of the circular RNA expression profile and circRNA–miRNA–mRNA network in the goat skin with divergent wool curvature

Animal Research and One Health, EarlyView., 2023
In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA‐seq. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation.
Yingxiao Su, Zhanqiang Zhao, Zhanfa Liu, Xiaobo Li, Qian Chen, Yabin Pu, Lin Jiang, Xiaohong He, Yuehui Ma, Qianjun Zhao   +9 more
wiley   +1 more source

Clinical significance of frizzled homolog 3 protein in colorectal cancer patients. [PDF]

PLoS ONE, 2013
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens.
Sze Chuen Cesar Wong, Catherine Wan He, Charles Ming Lok Chan, Amanda Kit Ching Chan, Heong Ting Wong, Moon Tong Cheung, Lewis Lai Yin Luk, Thomas Chi Chuen Au, Man Kin Chiu, Brigette Buig Yue Ma, Anthony Tak Cheung Chan   +10 more
doaj   +1 more source

Wnt Signaling: Pathogen Incursion and Immune Defense

Frontiers in Immunology, 2019
Wnt ligands interact with the transmembrane cell surface receptors Frizzled and ROR/RYK to initiate complex signaling cascades that are crucial for cell physiology and the proper functioning of the immune system.
Suborno Jati, Tresa Rani Sarraf, Debdut Naskar, Malini Sen   +3 more
doaj   +1 more source

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation

Frontiers in Molecular Neuroscience, 2021
The formation of synapses is a tightly regulated process that requires the coordinated assembly of the presynaptic and postsynaptic sides. Defects in synaptogenesis during development or in the adult can lead to neurodevelopmental disorders, neurological
Samuel Teo, Patricia C. Salinas
doaj   +1 more source

LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis [PDF]

Nature Communications, 2015
How Wnt signalling including canonical and non-canonical pathways are initiated at the cell surface is not completely understood. Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this interaction is regulated by the LRP6 ectodomain.
Yongyong Li, Shangfeng Liu, Shangfeng Liu, Jinxiao Chen, Zhongmin Liu, Jiankang Zhang, Yi Peng, Takashi K. Ito, Bo Chen, Zhi Li, Yan Yin, Yi-Han Chen, Yi-Han Chen, Xiaoling Lu, Hongwei Yan, Jianhua Yang, Linghui Pan, Da Wo, Luoquan Ao, Yongxiang Zhao, Dan-ni Ren, Weidong Zhu, Weidong Zhu   +22 more
openaire   +3 more sources

Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

eLife, 2019
During development, the nervous system undergoes a refinement process by which neurons initially extend an excess number of neurites, the majority of which will be eliminated by the mechanism called neurite pruning.
Menghao Lu, Kota Mizumoto
doaj   +1 more source

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. [PDF]

, 2015
Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types.
Baday, Yiressy C, Bao, Ju, Guibao, Cristina, Lee, Ho-Jin, Li, Lin, Miller, Ami, Wu, Dianqing, Wu, Jibo, Zhang, Chi, Zheng, Jie J   +9 more
core   +2 more sources