Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. [PDF]
PLoS ONE, 2012 The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can antagonize Wnt/β-catenin signaling, including the decoy receptors known as secreted frizzled related proteins (SFRPs), which ...
Ismaïl Hendaoui +8 more
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COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its "frizzled" motif is associated with obesity in diabetes type 2 patients [PDF]
Anais da Academia Brasileira de Ciências, 2008 Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signaling and Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis.
Flavia I.V. Errera +9 more
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Detection of CH25H gene polymorphism associated with growth traits of Yuexi frizzled chicken [PDF]
Poultry ScienceYuexi frizzled chicken has unique disease resistance and growth performance. Cholesterol 25-hydroxylase (CH25H) and its enzymatic product 25-hydroxycholesterol (25-HC) are recognized as key modulators of inflammatory signaling, immune defense, and viral ...
Yuying Li +6 more
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Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway [PDF]
Communications BiologyAdult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling ...
Pengfei Du +7 more
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How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? [PDF]
Open Biology, 2021 Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway.
Helen Strutt, David Strutt
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Frizzled receptors in melanomagenesis: From molecular interactions to target identification
Frontiers in Oncology, 2022 Frizzled (FZD) proteins are receptors for the WNT family ligands. Inherited human diseases and genetic experiments using knockout mice have revealed a central role of FZDs in multiple aspects of embryonic development and tissue homeostasis.
Sheikh A. Umar +4 more
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eLife, 2022 Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible patterning can be achieved with diffusing molecules, especially when that patterning concerns differentiation
Takayoshi Yamamoto +6 more
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Brain Sciences, 2022 It is well known that inflammation is crucial in the onset and progression of neurodegenerative diseases and traumatic central nervous system (CNS) injuries, and that microglia and monocyte-derived macrophages (MDMs) play a pivotal role in ...
Carlos González-Fernández +3 more
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Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer
Frontiers in Cell and Developmental Biology, 2021 Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis.
Yagmur Azbazdar +7 more
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Non-Coding RNA and Frizzled Receptors in Cancer
Frontiers in Molecular Biosciences, 2021 Frizzled receptors have been long recognized for their role in Wnt/β-catenin signaling, a pathway known for its tumorigenic effects. More recent studies of frizzled receptors include efforts to understand non-coding RNA (ncRNA) regulation of these ...
Alex J. Smith +3 more
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