Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. [PDF]
PLoS ONE, 2012 The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can antagonize Wnt/β-catenin signaling, including the decoy receptors known as secreted frizzled related proteins (SFRPs), which ...
Ismaïl Hendaoui +8 more
doaj +27 more sources
Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer [PDF]
Nature Communications, 2018 Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote
Virginia Murillo-Garzón +8 more
semanticscholar +5 more sources
How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? [PDF]
Open Biology, 2021 Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway.
Helen Strutt, David Strutt
doaj +1 more source
Immunohistochemical study of the canonical and non-canonical Wnt signaling pathway in colorectal carcinoma and non-neoplastic mucosa [PDF]
Journal of Coloproctology, 2015 Colorectal cancer is linked to several signaling pathways such as Wnt pathway. Our objective is to detect and verify the integrity of protein members of Wnt signaling pathway in colorectal carcinoma and non-neoplastic colorectal tissue.
Rodrigo Felippe Ramos +5 more
doaj +4 more sources
Frizzled receptors in melanomagenesis: From molecular interactions to target identification
Frontiers in Oncology, 2022 Frizzled (FZD) proteins are receptors for the WNT family ligands. Inherited human diseases and genetic experiments using knockout mice have revealed a central role of FZDs in multiple aspects of embryonic development and tissue homeostasis.
Sheikh A. Umar +4 more
doaj +1 more source
Journal of Cell Science, 2023 Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction.
Matthew Rickman +10 more
semanticscholar +1 more source
Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer
Frontiers in Cell and Developmental Biology, 2021 Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis.
Yagmur Azbazdar +7 more
doaj +1 more source
Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases
Frontiers in Endocrinology, 2021 Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be ...
Hua Guan +7 more
semanticscholar +1 more source
Phosphorylation of Frizzled-3 [PDF]
Journal of Biological Chemistry, 2006 Wnts are secreted proteins important to many biological processes. frizzled genes encode a family of Wnt receptors that signal to the intracellular compartment through the cytosolic protein Disheveled. Limited information is available concerning the regulation of Frizzleds at a biochemical level. We report here that Xenopus Frizzled-3 is phosphorylated
Robert J. Fagan +3 more
openaire +3 more sources
eLife, 2022 Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible patterning can be achieved with diffusing molecules, especially when that patterning concerns differentiation
Takayoshi Yamamoto +6 more
doaj +1 more source