Results 281 to 290 of about 57,889 (310)

Wnt-Frizzled Interactions in Xenopus

2008
The Wnt signaling cascades are regulatory modules which are involved in embryonic patterning, cell differentiation, morphogenesis, and diseases. The Wnt pathways are activated when secreted Wnt ligands interact with 7-trans-membrane receptors of the Frizzled (Fz) family.
Rajeeb K. Swain, Herbert Steinbeisser
openaire   +3 more sources

Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development

Development, 2001
Wnts are a family of secreted glycoproteins that are important for multiple steps in early development. Accumulating evidence suggests that frizzled genes encode receptors for Wnts. However, the mechanism through which frizzleds transduce a signal and the immediate downstream components that convey that signal are unclear.
Jing Yang, Arpine Arzoumanian, Peter S. Klein, Jean Pierre Saint-Jeannet, Change Tan, Matthew A. Deardorff   +5 more
openaire   +3 more sources

Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer

Life Sciences, 2001
Wnt signaling pathway is important for development and carcinogenesis. Alterations of this pathway, such as mutations in adenomatous polyposis coli (APC) gene and activation mutations of beta-catenin, would result in stabilization of beta-catenin and subsequent translocation to nucleus where genes are transcribed.
Chan, FKL, To, KF, Chan, MWY, Leung, WK, Yu, J, Tong, JHM, Lee, TL, Sung, JJY   +7 more
openaire   +5 more sources

Molecular Cloning, Differential Expression, and Chromosomal Localization of HumanFrizzled-1, Frizzled-2,andFrizzled-7

Biochemical and Biophysical Research Communications, 1998
cDNAs for three human Wnt receptors, Frizzled-1 (FZD1), Frizzled-2 (FZD2), and Frizzled-7 (FZD7), have now been cloned and characterized. The FZD1, FZD2, and FZD7 genes encode the 647-, 565-, and 574-amino-acid proteins, respectively. FZD1, FZD2, and FZD7 share a common structure consisting of seven transmembrane domains, a cysteine-rich domain in the ...
Masaru Katoh, Norihiko Sagara, Gotaro Toda, Masaaki Terada, Momoki Hirai   +4 more
openaire   +2 more sources

TcdB aims for Frizzled

Nature Reviews Microbiology, 2016
This study reveals that TcdB binds to two different receptors, CSPG4 and FZD, in a cell type-dependent manner.
openaire   +2 more sources

Wnt/frizzled signaling in hepatocellular carcinoma

Frontiers in Bioscience, 2006
The Wnt/Frizzled (FZD) signaling cascade is important for cell fate determination during embryonic development as well as maintaining tissue homeostasis in the adult. In addition to these physiologic roles, studies have shown that deregulation of Wnt/FZD signaling occurs during carcinogenesis.
Lee Hc, Miran Kim, Wands
openaire   +3 more sources

A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist.

Biochemistry, 2018
The WNT pathway interconnects a network of signaling events involved in a huge plethora of cellular processes, from organogenesis to tissue homeostasis. Despite its importance, the exiguity of organic drugs directly targeting the members of the Frizzled ...
Gennaro Riccio, Sara Bottone, G. La Regina, Nadia Badolati, Sara Passacantilli, G. Rossi, A. Accardo, M. Dentice, R. Silvestri, E. Novellino, Mariano Stornaiuolo   +10 more
semanticscholar   +1 more source

The emerging understanding of Frizzled receptors

FEBS Letters
The Wnt signaling pathway is a huge network governing development and homeostasis, dysregulation of which is associated with a myriad of human diseases. The Frizzled receptor (FZD) family comprises receptors for Wnt ligands, which indispensably mediate Wnt signaling jointly with a variety of co‐receptors.
Shaoqin Zheng, Ren Sheng
openaire   +2 more sources

Wnt receptor Frizzled 8 is a target of ERG in prostate cancer

The Prostate, 2018
Prostate cancer (PCa) is one of the most frequently diagnosed cancers among men. Many molecular changes have been detailed during PCa progression.
B. V. Chakravarthi, D. Chandrashekar, Sai Akshaya Hodigere Balasubramanya, Alyncia D. Robinson, Shannon Carskadon, Uttam Rao, J. Gordetsky, U. Manne, G. Netto, S. Sudarshan, N. Palanisamy, S. Varambally   +11 more
semanticscholar   +1 more source

Insights into Frizzled evolution and new perspectives

Evolution & Development, 2015
SUMMARYThe Frizzled proteins (FZDs) are a family of trans‐membrane receptors that play pivotal roles in Wnt pathways and thus in animal development. Based on evaluation of the Amphimedon queenslandica genome, it has been proposed that two Fzd genes may have been present before the split between demosponges and other animals.
Quentin Schenkelaars, Carole Borchiellini, Laura Fierro-Constain, Emmanuelle Renard, April Hill   +4 more
openaire   +3 more sources