Results 21 to 30 of about 56,649 (315)
Frizzled‐4 is required for normal bone acquisition despite compensation by Frizzled‐8 [PDF]
Journal of Cellular Physiology, 2020 AbstractThe activation of the Wnt/β‐catenin signaling pathway is critical for skeletal development but surprisingly little is known about the requirements for the specific frizzled (Fzd) receptors that recognize Wnt ligands. To define the contributions of individual Fzd proteins to osteoblast function, we profiled the expression of all 10 mammalian ...
Bart O. Williams +7 more
openaire +3 more sources
Brain Sciences, 2022 It is well known that inflammation is crucial in the onset and progression of neurodegenerative diseases and traumatic central nervous system (CNS) injuries, and that microglia and monocyte-derived macrophages (MDMs) play a pivotal role in ...
Carlos González-Fernández +3 more
doaj +1 more source
Animal Research and One Health, EarlyView., 2023 In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA‐seq. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation.
Yingxiao Su +9 more
wiley +1 more source
Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis
Cancer Research, 2020 Frizzled-7 marks platinum-tolerant cancer cells harboring stemness features and altered glutathione metabolism that depend on GPX4 for survival and are highly susceptible to ferroptosis.
Yinu Wang +13 more
semanticscholar +1 more source
Stem cell research & therapeutics, 2020 Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising therapeutic strategy for ischemic heart disease. However, its effects are hampered by the poor viability of transplanted cells and the hostile microenvironment of the ...
Mingzhuo Lin +9 more
semanticscholar +1 more source
Cancer Metastasis Review, 2020 Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) receptors, making potent regulators of Wnt signaling.
Karlijn van Loon +2 more
semanticscholar +1 more source
Clinical significance of frizzled homolog 3 protein in colorectal cancer patients. [PDF]
PLoS ONE, 2013 Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens.
Sze Chuen Cesar Wong +10 more
doaj +1 more source
The Emerging Mechanisms of Wnt Secretion and Signaling in Development
Frontiers in Cell and Developmental Biology, 2021 Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling pathways. These pathways regulate crucial processes during various stages of development and maintain tissue homeostasis in adults.
Shefali Mehta +2 more
doaj +1 more source
Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans
eLife, 2019 During development, the nervous system undergoes a refinement process by which neurons initially extend an excess number of neurites, the majority of which will be eliminated by the mechanism called neurite pruning.
Menghao Lu, Kota Mizumoto
doaj +1 more source
LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis [PDF]
Nature Communications, 2015 How Wnt signalling including canonical and non-canonical pathways are initiated at the cell surface is not completely understood. Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this interaction is regulated by the LRP6 ectodomain.
Yongyong Li +22 more
openaire +3 more sources