Results 21 to 30 of about 51,161 (270)
The evolution and expression of panarthropod frizzled genes [PDF]
Frontiers in Ecology and Evolution, 2015 Wnt signaling regulates many important processes during metazoan development. It has been shown that Wnt ligands represent an ancient and diverse family of proteins that likely function in complex signaling landscapes to induce target cells via receptors including those of the Frizzled (Fz) family.
Ralf Janssen +10 more
openaire +6 more sources
Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures [PDF]
, 2015 Background: In the last years, Wnt signaling was demonstrated to regulate inflammatory processes. In particular, an increased expression of Wnts and Frizzled receptors was reported in inflammatory bowel disease (IBD) and ulcerative colitis to exert both ...
Anne, Schuster +7 more
core +2 more sources
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core +2 more sources
Developmental Cell, 2004 The Wnt signaling network is arguably one of the most complex molecular modules by which cells communicate. Though we become accustomed to novel components, the discovery of an unexpected Wnt receptor ligand, Norrin, is surprising even to the connoisseur.
openaire +3 more sources
Frizzled Receptors in Development and Disease [PDF]
, 2016 Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr, Vangl, and a small number of additional membrane and membrane-associated proteins, they also play a central role in tissue polarity/planar cell polarity (PCP) signaling ...
Amir Rattner +3 more
openaire +3 more sources
TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis
eLife, 2020 Wnt signaling through the Frizzled (FZD) family of serpentine receptors is essential for embryogenesis and homeostasis, and stringent control of the FZD protein level is critical for stem cell regulation.
Maorong Chen +6 more
doaj +1 more source
Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas [PDF]
, 2011 Copyright © 2011 Cantilena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Cantilena, S +6 more
core +2 more sources
The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]
, 2019 Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi +12 more
core +1 more source
Cells, 2019 In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes.
Antonio García de Herreros +1 more
doaj +1 more source
WNT signalling in prostate cancer [PDF]
, 2017 Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours-particularly in the development of castration-
A Ghoshal +166 more
core +2 more sources