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Frizzled at the Cutting Edge of the Synapse [PDF]
Science, 2005 DFrizzled2 is a Drosophila member of the Frizzled family of Wnt receptors. In his Perspective, [Arias][1] discusses the findings by [ Mathew et al .][2] of Wingless association with DFrizzled2 in the fly neuromuscular junction. The interaction results in a surprising cleavage of the receptor's intracellular domain, an event that is required for the ...
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The Wnt/Frizzled GPCR signaling pathway
Biochemistry (Moscow), 2010G protein-coupled receptors (GPCRs) represent the biggest transmembrane receptor family. The Frizzled group of GPCRs is evolutionarily conserved and serves to transduce signals from the Wnt-type lipoglycoprotein growth factors. The Wnt/Frizzled signaling cascades are repeatedly used during animal development and are mostly silent in the adult. Improper
Vladimir L. Katanaev +1 more
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Wnt/Frizzled Signaling in the Vasculature [PDF]
, 2014 Signaling, by the Wnt family of secreted glycolipoproteins, is one of the fundamental mechanisms that direct cell proliferation, polarity, and fate determination during embryonic development and tissue homeostasis. Recent advances in vascular biology highlight important roles for multiple components of the Wnt-signaling pathway in regulating ...
Pascale Dufourcq +2 more
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Wnt and Frizzled Genes in Echinoderms
Russian Journal of Marine Biology, 2019Wnt and frizzled genes of 17 echinoderm species were studied by molecular and bioinformatics methods. As a result, it has been found that echinoderms have 11–13 wnt genes and four frizzled genes. The phylum Echinodermata is generally characterized by the loss of some of the Wnt family genes. In particular, members of all classes, except for Asteroidea,
A. V. Boyko, Alexander S. Girich
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Wnt/Frizzled signaling in Ewing sarcoma
Pediatric Blood & Cancer, 2004AbstractBackgroundThe Ewing sarcoma family of tumors (ESFT) is a set of neuroectodermal malignancies that typically presents in the second decade and has a poor prognosis due to metastatic disease. Wnt signaling has a critical role in the normal development of multiple neuroectodermal tissues and also contributes to the neoplastic properties of tumor ...
Vladimir Wolf +5 more
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Nature Cell Biology, 2003
nt signalling pathways regulate cell proliferation, cell fate and morphogenetic movements. Here, we demonstrate that the Frizzled (Fz) family of Wnt receptors, similarly to G-protein-coupled receptors (GPCRs), form specific homo- and hetero-oligomers.
Kavita V. Shah +5 more
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nt signalling pathways regulate cell proliferation, cell fate and morphogenetic movements. Here, we demonstrate that the Frizzled (Fz) family of Wnt receptors, similarly to G-protein-coupled receptors (GPCRs), form specific homo- and hetero-oligomers.
Kavita V. Shah +5 more
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Non‐conventional Frizzled ligands and Wnt receptors
Development, Growth & Differentiation, 2008The Wnt family of secreted signaling factors plays numerous roles in embryonic development and in stem cell biology. In the adult, Wnt signaling is involved in tissue homeostasis and mutations that lead to the overexpression of Wnt can be linked to cancer. Wnt signaling is transduced intracellularly by the Frizzled (Fzd) family of receptors.
Hendrickx, Marijke, Leyns, Luc
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Biochemical and Biophysical Research Communications, 2000
Frizzled genes, encoding WNT receptors, play key roles in cell fate determination. Here, we isolated two Xenopus frizzled genes (Xfz10A and Xfz10B), probably reflecting pseudotetraploidy in Xenopus. Xfz10A (586 amino acids) and Xfz10B (580 amino acids) both encoded by a single exon, consisted of the N-terminal cysteine-rich domain, seven transmembrane ...
Tetsuroh Saitoh +9 more
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Frizzled genes, encoding WNT receptors, play key roles in cell fate determination. Here, we isolated two Xenopus frizzled genes (Xfz10A and Xfz10B), probably reflecting pseudotetraploidy in Xenopus. Xfz10A (586 amino acids) and Xfz10B (580 amino acids) both encoded by a single exon, consisted of the N-terminal cysteine-rich domain, seven transmembrane ...
Tetsuroh Saitoh +9 more
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Crystal structure of a mammalian Wnt–frizzled complex
Nature Structural & Molecular Biology, 2019Hidenori Hirai +4 more
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