Interaction of Frizzled 7 and Dishevelled in Xenopus [PDF]
Developmental Dynamics, 2000 Frizzled proteins act as putative Wnt receptors and depending on Wnt/Frizzled interactions distinct intracellular pathways can be activated. The canonical Wnt pathway, triggered by Wnt-1-type ligands, is the best characterized and involves the activation of the cytoplasmic protein Dishevelled (Dsh). The Xenopus frizzled 7 receptor (Xfz7) can act in the
Araceli Medina, Herbert Steinbeisser
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Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity [PDF]
, 2016 Objective: This study aimed to evaluate whether circulating levels and/or visceral adipose tissue (VAT) expression of recently described adipokines associate with histopathological severity of nonalcoholic fatty liver disease (NAFLD), independent of ...
Alfadda +39 more
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Deregulation of Frizzled Receptors in Hepatocellular Carcinoma [PDF]
International Journal of Molecular Sciences, 2018 G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a “cancer driver”. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression.
Kristy Kwan-Shuen Chan +2 more
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eLife, 2015 The flight muscles, dorsal air sacs, wing blades, and thoracic cuticle of the Drosophila adult function in concert, and their progenitor cells develop together in the wing imaginal disc.
Hai Huang, Thomas B Kornberg
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Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer [PDF]
, 2018 Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote
Carton, J +8 more
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Regulation of Endothelial Cell Cytoskeletal Reorganization by a Secreted Frizzled-Related Protein-1 and Frizzled 4- and Frizzled 7-Dependent Pathway [PDF]
The American Journal of Pathology, 2008 Consistent with findings of Wnt pathway members involved in vascular cells, a role for Wnt/Frizzled signaling has recently emerged in vascular cell development. Among the few Wnt family members implicated in vessel formation in adult, Wnt7b and Frizzled 4 have been shown as involved in vessel formation in the lung and in the retina, respectively.
Caroline Basoni +10 more
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Wnt-3a Induces Cytokine Release in Human Mast Cells
Cells, 2019 Mast cells are well known for their detrimental effects in allergies and asthma, and Wnt signaling has recently been implicated in asthma and other airway diseases. However, it is not known if or how Wnts affect human mast cells.
Julia Tebroke +5 more
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The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]
, 2014 G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin +8 more
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Wnt Receptor Frizzled-4 as a Marker for Isolation of Enteric Neural Progenitors in Human Children
Cells, 2019 Identification and isolation of neural progenitor cells from the human enteric nervous system (ENS) is currently hampered by the lack of reliable, specific markers.
Peter H. Neckel +8 more
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Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. [PDF]
PLoS ONE, 2012 BackgroundWnt proteins are a large family of molecules that are critically involved in multiple central nervous system (CNS) developmental processes.
Pau Gonzalez +4 more
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