TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis
eLife, 2020 Wnt signaling through the Frizzled (FZD) family of serpentine receptors is essential for embryogenesis and homeostasis, and stringent control of the FZD protein level is critical for stem cell regulation.
Maorong Chen +6 more
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Interaction of Frizzled 7 and Dishevelled in Xenopus [PDF]
Developmental Dynamics, 2000 Frizzled proteins act as putative Wnt receptors and depending on Wnt/Frizzled interactions distinct intracellular pathways can be activated. The canonical Wnt pathway, triggered by Wnt-1-type ligands, is the best characterized and involves the activation of the cytoplasmic protein Dishevelled (Dsh). The Xenopus frizzled 7 receptor (Xfz7) can act in the
Araceli Medina, Herbert Steinbeisser
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Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 [PDF]
, 2002 In Drosophila, the frizzled gene plays a critical role in the establishment of tissue polarity, but the function of the Frizzled family of proteins in mammals is largely unknown.
Hering, Heike, Sheng, Morgan
core +1 more source
Regulation of Endothelial Cell Cytoskeletal Reorganization by a Secreted Frizzled-Related Protein-1 and Frizzled 4- and Frizzled 7-Dependent Pathway [PDF]
The American Journal of Pathology, 2008 Consistent with findings of Wnt pathway members involved in vascular cells, a role for Wnt/Frizzled signaling has recently emerged in vascular cell development. Among the few Wnt family members implicated in vessel formation in adult, Wnt7b and Frizzled 4 have been shown as involved in vessel formation in the lung and in the retina, respectively.
Caroline Basoni +10 more
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eLife, 2015 The flight muscles, dorsal air sacs, wing blades, and thoracic cuticle of the Drosophila adult function in concert, and their progenitor cells develop together in the wing imaginal disc.
Hai Huang, Thomas B Kornberg
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The distribution of Dishevelled in convergently extending mesoderm [PDF]
, 2013 Convergent extension (CE) is a conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity (PCP) pathway.
Aigouy +61 more
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Wnt Receptor Frizzled-4 as a Marker for Isolation of Enteric Neural Progenitors in Human Children
Cells, 2019 Identification and isolation of neural progenitor cells from the human enteric nervous system (ENS) is currently hampered by the lack of reliable, specific markers.
Peter H. Neckel +8 more
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Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling [PDF]
, 2015 Peer reviewedPublisher ...
Abal, Miguel +14 more
core +5 more sources
Wnt-3a Induces Cytokine Release in Human Mast Cells
Cells, 2019 Mast cells are well known for their detrimental effects in allergies and asthma, and Wnt signaling has recently been implicated in asthma and other airway diseases. However, it is not known if or how Wnts affect human mast cells.
Julia Tebroke +5 more
doaj +1 more source
Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. [PDF]
PLoS ONE, 2012 BackgroundWnt proteins are a large family of molecules that are critically involved in multiple central nervous system (CNS) developmental processes.
Pau Gonzalez +4 more
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