Results 51 to 60 of about 51,161 (270)

Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. [PDF]

, 2010
An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression.
Amengual, J., Bonet, M.L., Bunschoten, A., Godschalk, R.W.L., Heil, S.G., Helden, Y.G.J., Hessel, S., Keijer, J., Lintig, J., von, Schooten, F.J., van   +9 more
core   +2 more sources

FRZB (frizzled-related protein) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on FRZB (frizzled-related protein), with data on DNA, on the protein encoded, and where the gene is implicated.
Thysen, S, Lories, R
openaire   +3 more sources

Wnt/β-Catenin Signaling as a Molecular Target by Pathogenic Bacteria

Frontiers in Immunology, 2019
The Wnt/β-catenin signaling pathway is crucial to regulate cell proliferation and polarity, cell determination, and tissue homeostasis. The activation of Wnt/β-catenin signaling is based on the interaction between Wnt glycoproteins and seven ...
Octavio Silva-García, Juan J. Valdez-Alarcón, Víctor M. Baizabal-Aguirre   +2 more
doaj   +1 more source

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. [PDF]

, 2013
Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway.
Bao, Ju, Carroll, Candace E, Grace, Christy RR, Guibao, Cristina D, Lee, Ho-Jin, Marada, Suresh, Ogden, Stacey K, Rana, Rajashree, Zheng, Jie J   +8 more
core   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]

, 2009
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core   +1 more source

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]

, 2017
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves, Couraud, Pierre-Olivier, Mauborgne, Annie, Moreau, Nathan, Pohl, Michel, Romero, Ignacio A, Villanueva, Luis, Weksler, Babette B   +7 more
core   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its "frizzled" motif is associated with obesity in diabetes type 2 patients

Anais da Academia Brasileira de Ciências, 2008
Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signaling and Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis.
Flavia I.V. Errera, Luís H. Canani, Erika Yeh, Érika Kague, Lucia M. Armelin-Corrêa, Oscar T. Suzuki, Balduíno Tschiedel, Maria Elizabeth R. Silva, Andréa L. Sertié, Maria Rita Passos-Bueno   +9 more
doaj   +1 more source

Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive

Toxins, 2020
Toxin B (TcdB) produced by Clostridioides difficile is a main pathogenicity factor that affects a variety of different cell types within the colonic mucosa. TcdB is known to utilize frizzled-1,2,7 and chondroitin sulfate proteoglycan-4 (CSPG4) as protein
Daniel Henkel, Helma Tatge, Dennis Schöttelndreier, Liang Tao, Min Dong, Ralf Gerhard   +5 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source