The wnt-frizzled cascade in cardiovascular disease [PDF]
Cardiovascular Research, 2002 Time for primary review 31 days. Wnt-proteins constitute a family of secreted cystein-rich glycosylated proteins, involved in a variety of modeling and remodeling processes including cell proliferation, differentiation, apoptosis and the control of cell orientation [1–3].
Jos F.M. Smits +3 more
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Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]
, 2017 BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves +7 more
core +3 more sources
Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
International Journal of Molecular Sciences, 2018 Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway.
Chui-Mian Zeng, Zhe Chen, L. Fu
semanticscholar +1 more source
FRZB (frizzled-related protein) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on FRZB (frizzled-related protein), with data on DNA, on the protein encoded, and where the gene is implicated.
Thysen, S, Lories, R
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Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Capovilla, Simon +8 more
core +2 more sources
G3: Genes, Genomes, Genetics, 2016 Most mutant alleles in the Fz-PCP pathway genes were discovered in classic Drosophila screens looking for recessive loss-of-function (LOF) mutations. Nonetheless, although Fz-PCP signaling is sensitive to increased doses of PCP gene products, not many ...
Jose Maria Carvajal-Gonzalez +3 more
doaj +1 more source
Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).
Annual Review of Cell and Developmental Biology, 2015 The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a critical, evolutionarily conserved process during development and organogenesis.
Yingzi Yang, M. Mlodzik
semanticscholar +1 more source
Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance [PDF]
, 2016 Background A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior.
Purdy, Ashley M. +2 more
core +2 more sources
Wnt/β-Catenin Signaling as a Molecular Target by Pathogenic Bacteria
Frontiers in Immunology, 2019 The Wnt/β-catenin signaling pathway is crucial to regulate cell proliferation and polarity, cell determination, and tissue homeostasis. The activation of Wnt/β-catenin signaling is based on the interaction between Wnt glycoproteins and seven ...
Octavio Silva-García +2 more
doaj +1 more source
eLife, 2019 The molecular basis of Wnt-Frizzled specificity is a central question in developmental biology. Reck, a multi-domain and multi-functional glycosylphosphatidylinositol-anchored protein, specifically enhances beta-catenin signaling by Wnt7a and Wnt7b in ...
Chris Cho +4 more
semanticscholar +1 more source