Results 81 to 90 of about 51,161 (270)

Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis

Glia, EarlyView.
OECs are similar to satellite glial cells. OECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. OECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs) envelope ...
Katja Senf, Sandor Nietzsche, Martin Westermann, Eva M. Neuhaus   +3 more
wiley   +1 more source

The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. [PDF]

PLoS Genetics, 2015
Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5.
Naomi Levy-Strumpf, Meghan Krizus, Hong Zheng, Louise Brown, Joseph G Culotti   +4 more
doaj   +1 more source

Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development

The International Journal of Developmental Biology, 2004
Recent studies indicate a role for Wnt signaling in regulating lens cell differentiation (Stump et al., 2003). Here we investigated expression patterns of Wnt receptors, the Frizzleds (Fzs) and the Wnt signaling regulators, the secreted frizzled-related proteins (Sfrps), during rodent lens development.
Yongjuan Chen, John W. McAvoy, Frank J. Lovicu, R.J.W. Stump   +3 more
openaire   +4 more sources

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Wnt signaling: A complex issue

Biological Research, 2002
The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification.
BART HENDRIKS, ERNST REICHMANN
doaj  

Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants

Stem Cells International, 2016
The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors.
Katharina Nothelfer, Florian Obermayr, Nadine Belz, Ellen Reinartz, Petra M. Bareiss, Hans-Jörg Bühring, Rudi Beschorner, Lothar Just   +7 more
doaj   +1 more source

The Role of Intracellular Interactions in the Collective Polarization of Tissues and its Interplay with Cellular Geometry

, 2019
Planar cell polarity (PCP), the coherent in-plane polarization of a tissue on multicellular length scales, provides directional information that guides a multitude of developmental processes at cellular and tissue levels.
Mani, Madhav, Shadkhoo, Shahriar
core   +1 more source

Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon [PDF]

, 2012
The anterior commissure forms the first axon connections between the two sides of the embryonic telencephalon. We investigated the role of the transmembrane receptor Frizzled-3a in the development of this commissure using zebrafish as an experimental ...
Abramoff, Akimenko, Armstrong, Barresi, Bhanot, Brian Key, Briancon-Marjollet, Carron, Chitnis, Christine A. Devine, Ciruna, Danesin, Dann, Devine, Falk, Fazeli, Fjose, Frohman, Gerety, Hjorth, Hjorth, Houart, Hutson, Hutson, Joseph A. Rothnagel, Kassai, Kawahara, Krauss, Krauss, Kullander, Lauderdale, Lindwall, Lyuksyutova, Miyasaka, Molven, Nona, Robu, Ross, Serafini, Sheldahl, Slusarski, Slusarski, Strähle, Suto, Turner, Wada, Wang, Wang, Wang, Widelitz, Wilson, Wolfgang Hofmeister, Xiao, Zhou   +53 more
core   +1 more source

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Med Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang, Yanyun Pang, Peijia Zhu, Zhengdong Zhang, Sen Guo, Zhijian Wei, Wenzhao Wang, Bin Ning   +7 more
wiley   +1 more source

The pathological role of Wnt5a in psoriasis and psoriatic arthritis. [PDF]

, 2019
Psoriasis (PsO) is a chronic inflammatory skin disease with both local and systemic components. PsO-associated arthritis, known as psoriatic arthritis (PsA), develops in approximately 13%-25% of PsO patients.
Li, Zhengxiao, Mauro, Theodora M, Tian, Faming   +2 more
core   +1 more source