Results 111 to 120 of about 19,373 (224)

Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8

Mechanisms of Development, 2003
The dorsal ectoderm of vertebrate gastrula is first specified into anterior fate by an activation signal and posteriorized by a graded transforming signal, leading to the formation of forebrain, midbrain, hindbrain and spinal cord along the anteroposterior (A-P) axis.
Momoi, A., Yoda, H., Steinbeisser, H., Fagotto, F, . Kondoh, H., Kudo, A., Driever, W., Furutani-Seiki, M.   +7 more
openaire   +4 more sources

Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo. [PDF]

J Biol Chem, 2022
Zhang Y, Wang Y, Zheng G, Liu Y, Li J, Huang H, Xu C, Zeng Y, Zhang X, Qin J, Dai C, Hambrock HO, Hartmann U, Feng B, Mak KK, Liu Y, Lan HY, Huang Y, Zheng ZH, Xia Y.   +19 more
europepmc   +1 more source

Fabrication of Fructooligosaccharide‐Larimichthys crocea Peptide Copolymer by Wet‐Heating for Enhanced Calcium Delivery and Bone‐Lipid Metabolism Regulation

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
A food‐derived fructooligosaccharide‐Larimichthys crocea peptide (FOS‐LCP) copolymer was prepared by wet‐heating and exhibited high calcium‐binding capacity and enhanced intestinal calcium uptake compared with native peptides. In bone marrow mesenchymal stem cells from calcium‐deficient mice, FOS‐LCP was found to promote osteogenesis while suppressing ...
Chunlei Liu, Xiaoping Wu, Yihang Guo, Dan Li   +3 more
wiley   +1 more source

Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies. [PDF]

Oncol Res, 2021
Sun Y, Wang W, Zhao C.
europepmc   +1 more source

γ-Neurexin and Frizzled Mediate Parallel Synapse Assembly Pathways Antagonized by Receptor Endocytosis [PDF]

, 2018
Peri T. Kurshan, Sean A. Merrill, Yongming Dong, Chen Ding, Marc Hammarlund, Jihong Bai, Erik M. Jørgensen, Kang Shen   +7 more
openalex   +1 more source

Identification of a Novel Functional Non-synonymous Single Nucleotide Polymorphism in Frizzled Class Receptor 6 Gene for Involvement in Depressive Symptoms

, 2022
Haijun Han, Mengxiang Xu, Wen Li, Jiali Chen, Qiang Liu, Ju Wang, Ming D. Li, Zhongli Yang   +7 more
openalex   +1 more source

Myofibroblast‐Derived Extracellular Vesicles Drive Profibrotic Cascade Amplification in Pulmonary Fibrosis via the Nestin‐Rab7 Axis

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease characterized by aberrant myofibroblast activation and excessive extracellular matrix deposition, with extracellular vesicles (EVs) playing a crucial role in this pathological process. We observed that EVs levels are significantly elevated in IPF and positively correlate with
Xiaofan Lai, Yong Xiao, Yingying Lin, Senyu Yao, Bin Wang, Hainan Chen, Tianxiang Lei, Shaojie Huang, Chenxing Lei, Qihao Zeng, Yuan Qiu, Hong Chen, Tao Wang, Jiancheng Wang, Andy Peng Xiang   +14 more
wiley   +1 more source

Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape

Molecular Medicine, 2019
The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique disulfide bridge pattern which attains a correct fold in the ER.
Reham M. Milhem, Bassam R. Ali
doaj   +1 more source

Oral Delivery of R‐spondin1‐Loaded Small Extracellular Vesicles Activates WNT Signalling Pathway to Accelerate Intestinal Injury Repair and Reverse Ageing

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Yang et al. demonstrated that HSPG mediate the loading of active R‐spondin1 protein onto the surface of small extracellular vesicles (evRSPO1). evRSPO1 induced WNT/β‐catenin activity in intestinal organoids and tissues, thereby regulating intestinal stem cells proliferation.
Lingyan Yang, Xu Wang, Xiyang Wei, Pei Yu, Yue Liu, Shixiang Wang, Yuefang Lin, Yue Yang, Ting Jiang, Zhiping Qiao, Jiaxiang Zhang, Shicheng Yu, Ye‐Guang Chen, Yun‐Shen Chan   +13 more
wiley   +1 more source

Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity.

PLoS Biology, 2004
The Frizzled (Fz; called here Fz1) and Fz2 receptors have distinct signaling specificities activating either the canonical Wnt/beta-catenin pathway or Fz/planar cell polarity (PCP) signaling in Drosophila.
Jun Wu, Thomas J Klein, Marek Mlodzik
doaj   +1 more source