Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model [PDF]
, 2022 Lukas Grätz +6 more
openalex +1 more source
Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo. [PDF]
J Biol Chem, 2022 Zhang Y +19 more
europepmc +1 more source
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape
Molecular Medicine, 2019 The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique disulfide bridge pattern which attains a correct fold in the ER.
Reham M. Milhem, Bassam R. Ali
doaj +1 more source
Frizzled Receptors Activate a Novel JNK-Dependent Pathway that May Lead to Apoptosis [PDF]
, 2002 Mikhail Lisovsky +2 more
openalex +1 more source
Estudo do receptor Frizzled classe 9 (FZD9), um potencial biomarcador prognóstico e alvo terapêutico [PDF]
, 2023 Daniel Rodrigues de Bastos
openalex +1 more source
Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies. [PDF]
Oncol Res, 2021 Sun Y, Wang W, Zhao C.
europepmc +1 more source
G protein‐coupled receptor‐mediated autophagy in health and disease
British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan +2 more
wiley +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3225-3248, July 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source