Results 61 to 70 of about 364,393 (335)

Diagnostic Challenge in Frontal Variant Alzheimer's Disease With Low Amyloid‐β PET Retention

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diagnosing frontal variant Alzheimer's disease (fvAD) is difficult and could be even more difficult when amyloid‐beta (Aβ) PET retention is low. A 63‐year‐old woman presenting with a 3‐year history of apathy and memory impairment showed executive dysfunction, memory impairment, and severe bilateral frontotemporal atrophy on MRI.
Ryosuke Shimasaki, Masanori Kurihara, Kenji Ishibashi, Aya Midori Tokumaru, Kenji Ishii, Atsushi Iwata   +5 more
wiley   +1 more source

Partnering with people living with dementia and care partners in technology research and design: Reflections and recommendations

Australian Occupational Therapy Journal, Volume 69, Issue 6, Page 723-741, December 2022., 2022
Abstract Introduction Occupational therapists may recommend and support technology use for facilitating independence, safety, wellbeing, and participation. There are high expectations for technology for people living with dementia. However, there is recognition that technologies will need to improve to deliver these expected benefits.
Jacki Liddle, Peter Worthy, Dennis Frost, Eileen Taylor, Dubhglas Taylor   +4 more
wiley   +1 more source

Comparison of prefrontal atrophy and episodic memory performance in dysexecutive Alzheimer’s disease and behavioural-variant frontotemporal dementia [PDF]

, 2016
Alzheimer’s disease (AD) sometimes presents with prominent executive dysfunction and associated prefrontal cortex atrophy. The impact of such executive deficits on episodic memory performance as well as their neural correlates in AD, however, remains ...
Alvarez, Ashburner, Bertoux, Bertoux, Binetti, Blennerhassett, Burgess, Chang, de Souza, Delis, Dickerson, Dunn, Fernandez-Calvo, Forman, Frisch, Gilbert, Gleichgerrcht, Gleichgerrcht, Godefroy, Good, Graham, Gregory, Hodges, Hornberger, Hornberger, Hornberger, Irish, Johnson, Kipps, Kopelman, Larner, Liu, Long, McKhann, Meyers, Mez, Mioshi, Mioshi, Moayedi, Morris, Nestor, Nichols, Ossenkoppele, Pa, Pennington, Possin, Rascovsky, Reitan, Rueckert, Savage, Schmidt, Seeley, Smith, Somerville, Swanberg, Torralva, Wedderburn, Wong, Woodward, Woodward, Woodward, Woodward, Zhang, Zheng   +63 more
core   +1 more source

Dysphagia and Mortality Risk in Individuals With Primary Progressive Apraxia of Speech

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Individuals with primary progressive apraxia of speech (PPAOS) often develop parkinsonism and dysphagia. To evaluate the clinical correlates and impact of dysphagia in this population, we compared enrollment visit data between individuals with (n = 12) versus individuals without (n = 44) dysphagia symptoms.
Gabriela Meade, Nha Trang Thu Pham, Sarah M. Boland, Heather M. Clark, Joseph R. Duffy, Jennifer L. Whitwell, Hugo Botha, Keith A. Josephs, Rene L. Utianski   +8 more
wiley   +1 more source

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers. [PDF]

, 2019
Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Gunter, Jeffrey L, Haley, Dana, Jones, David, Kantarci, Kejal, Knopman, David, Kraft, Ruth, Lapid, Maria, Lesnick, Timothy, Rademakers, Rosa, Rosen, Howie, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +22 more
core   +3 more sources

A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen, Zanna J. Voysey, Jonathan A. Holbrook, Maura Malpetti, Clara Le Draoulec, Lennart R. B. Spindler, Anna O. G. Goodman, Alpar S. Lazar, Roger A. Barker   +8 more
wiley   +1 more source

A retrospective study of the behavioural and psychological symptoms of dementia in patients admitted to a Specialist Dementia Care Unit

Australasian Journal on Ageing, Volume 41, Issue 4, Page e397-e405, December 2022., 2022
Abstract Objectives To explore the nature and severity of behavioural and psychological symptoms of dementia (BPSD) and outcomes for patients admitted to a specialist dementia care unit (SDCU) at a tertiary Australian hospital. Methods This single‐centre retrospective study categorised patients into a recognised seven‐tiered model of severity of BPSD ...
Kate Djekovic, Kim Clowes, Natasha Spalding, Louise Waite   +3 more
wiley   +1 more source

Neural Substrates of Semantic Prospection – Evidence from the Dementias [PDF]

, 2016
The ability to envisage personally relevant events at a future time point represents an incredibly sophisticated cognitive endeavor and one that appears to be intimately linked to episodic memory integrity.
Abraham, Addis, Addis, Addis, Andelman, Andersson, Andersson, Ashburner, Botzung, Claire O’Callaghan, Cooper, Dermody, Duval, D’Argembeau, Frisch, Greenberg, Hassabis, Hornberger, Irish, Irish, Irish, Irish, Irish, Irish, Irish, Irish, Irish, Irish, John R. Hodges, Karantoulis, Karas, Klein, Klein, Klein, Kwan, Manning, McKhann, Mechelli, Michael Hornberger, Mioshi, Mioshi, Morris, Muireann Irish, Mullally, Mullally, Nadene Dermody, Nadine Eyre, Nichols, Okuda, Olivier Piguet, Piolino, Race, Race, Rascovsky, Reitan, Rey, Rosen, Rueckert, Savage, Schacter, Schacter, Schacter, Schmidt, Smith, Smith, Squire, Strauss, Suddendorf, Szpunar, Szpunar, Wechsler, Westmacott, Zhang   +72 more
core   +2 more sources

KIF5A p.Pro986Leu Risk Variant and Accelerated Progression of Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study explored the impact of KIF5A rs113247976 (p.Pro986Leu), a risk allele for amyotrophic lateral sclerosis (ALS), on phenotypic variability in two Italian ALS cohorts (discovery, n = 865; replication, n = 1174). The minor allele (T) frequency was 0.015.
Arianna Manini, Rosario Vasta, Alberto Brusati, Francesco Scheveger, Silvia Peverelli, Alessio Maranzano, Alberto Doretti, Francesco Gentile, Eleonora Colombo, Maura Brunetti, Cristina Moglia, Antonio Canosa, Umberto Manera, Maurizio Grassano, Davide Gentilini, Stefano Messina, Federico Verde, Claudia Morelli, John E. Landers, Bryan J. Traynor, Adriano Chiò, Vincenzo Silani, Andrea Calvo, Antonia Ratti, Nicola Ticozzi   +24 more
wiley   +1 more source

Demographic and clinical profile of residents living with dementia and depressive symptoms in Australian private residential aged care: Data from the Music Interventions for Dementia and Depression in ELderly care (MIDDEL) cluster‐randomised controlled trial

Australasian Journal on Ageing, Volume 41, Issue 4, Page e387-e396, December 2022., 2022
Abstract Objectives 1) To describe the demographic and clinical characteristics of residents with dementia and depressive symptoms in the Australian private residential aged care (RAC) context; and 2) to investigate the association between neuropsychiatric symptoms, depression and quality of life and their interactions with dementia severity.
Young‐Eun C. Lee, Tanara Vieira Sousa, Phoebe A. Stretton‐Smith, Christian Gold, Monika Geretsegger, Felicity A. Baker   +5 more
wiley   +1 more source