Results 81 to 90 of about 21,388 (227)

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Negative neurofilament light and tau immunostaining in frontotemporal dementia

, 2004
We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with ...
Englund, Elisabet,, Sjogren, M, Lund University.   +2 more
core   +1 more source

Interictal Epileptiform Activity in the Foramen Ovale Electrodes of a Frontotemporal Dementia Patient

Journal of Alzheimer's Disease Reports, 2017
Frontotemporal dementia (FTD) is a frequent cause of cognitive decline. While epilepsy is an important comorbidity of Alzheimer’s disease, we lack studies on its presence in FTD.
András Horváth, Anna Szűcs, Gábor Barcs, Dániel Fabó, Anna Kelemen, Péter Halász, Loránd Erőss, Anita Kamondi   +7 more
doaj   +1 more source

C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression

Nature Communications, 2020
C9orf72 repeat expansion is the major genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, the authors show that transcriptome aberrations commonly found in c9ALS/FTD are a result from defects in cellular
Yu Sun, Aziz Eshov, Jeffrey Zhou, Atagun U. Isiktas, Junjie U. Guo   +4 more
doaj   +1 more source

Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study

Journal of Neuroinflammation, 2022
Background Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers
Emma L. van der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David McFall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G. P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Yolande A. L. Pijnenburg, Markus Otto, Barbara Borroni, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Daniela Galimberti, Sandro Sorbi, Henrik Zetterberg, Eric Huang, John C. van Swieten, Jonathan D. Rohrer, Harro Seelaar, the Genetic Frontotemporal Dementia Initiative (GENFI)   +44 more
doaj   +1 more source

Resolution of Levodopa/Dopa‐Decarboxylase Inhibitor—Associated Microscopic Colitis with Subcutaneous Foslevodopa/Foscarbidopa: A Case Series and Review of the Literature

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Microscopic colitis (MC) typically presents with chronic, non‐bloody watery diarrhea. Diagnosis requires endoscopy with colonic mucosal biopsies. The etiology is multifactorial, with several medications implicated, although only a few cases have been attributed to oral levodopa/dopa‐decarboxylase inhibitor (LDDCI) therapy.
Romana Hintner, Franziska Eberhardt, Manuela Kofler, Andreas Eigentler, Atbin Djamshidian, Florian Krismer, Anton Hittmair, Heinz Zoller, Valentina Ellinger, Beatrice Heim, Klaus Seppi   +10 more
wiley   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Chromosome 9 ALS and FTD locus is probably derived from a single founder.

, 2012
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations.
Shatunov, A., Rollinson, PS, DeJesus-Hernandez, M, Pentti J. Tienari, Boxer, A.L., Hardy, J, Laaksovirta, H., Morrison, Karen E., Hardy, J., Aleksey Shatunov, John C. van Swieten, Rademakers, R, Restagno, Gabriella, Boeve, B.F., Bryan J. Traynor, Rollinson, Pamela Sara, Karen E. Morrison, Al-Chalabi, A., Ian R. Mackenzie, Morris, Huw Rees, Traynor, BJ, Mariely DeJesus-Hernandez, Jesus-Hernandez, M., Mackenzie, I.R., Morrison, KE, Orrell, R.W., Pamela Sara Rollinson, Mackenzie, Ian R., Simón-Sánchez, J, Nalls, MA, van Swieten, J.C., Waite, Adrian, Javier Simón-Sánchez, Tienari, P.J., Boeve, Bradley F., Morrison, Karen, Nalls, Michael A., Restagno, G, Myllykangas, L, Boxer, Adam L., Waite, Adrian James, Ammar Al-Chalabi, Waite, A, Mora, G, Heutink, P, Boeve, BF, Traynor, Bryan J., Waite, A., Adam L. Boxer, Shatunov, Aleksey, Rosa Rademakers, DeJesus-Hernandez, Mariely, Mackenzie, IR, Nigel Williams, Pickering-Brown, S, Hannu Laaksovirta, Chiò, A, Schymick, J., Williams, N, Simón-Sánchez, Javier, Laaksovirta, Hannu, Mok, K, Laaksovirta, H, Adrian Waite, Shaw, Pamela J., Pickering-Brown, Stuart, Rademakers, Rosa, Heutink, Peter, Mok, K., van Swieten, JC, Tienari, PJ, Liisa Myllykangas, Peuralinna, T, Heutink, P., Rollinson, P.S., Morris, HR, Hardy, John, Schymick, J, Shatunov, A, John Hardy, Simon-Sanchez, J., Huw R. Morris, Gabriele Mora, Morris, H.R., Peuralinna, T., Rademakers, R., Morrison, K.E., Mora, G., Pickering-Brown, S., Peuralinna, Terhi, Chio', Adriano, Peter Heutink, Richard W. Orrell, Chio, A., Terhi Peuralinna, Morrison, Karen E.; id_orcid, Myllykangas, Liisa, Williams, Nigel, Bradley F. Boeve, Gabriella Restagno, Pamela J. Shaw, Orrell, RW, Traynor, B.J., Shatunov, Aleksey; id_orcid, Kin Mok, Nalls, M.A., Al-Chalabi, Ammar, Williams, N., Boxer, AL, Shaw, P.J., Myllykangas, L., Mok, Kin, Mora, Gabriele, Orrell, Richard W., Tienari, Pentti J., Adriano Chiò, Schymick, Jennifer, Morris, Huw R., Shaw, PJ, Williams, Nigel Melville, Al-Chalabi, A, Chiò, Adriano, Restagno, G., van Swieten, John C., Michael A. Nalls, Stuart Pickering-Brown, Jennifer Schymick   +126 more
core   +1 more source

FRONTOTEMPORAL DEMENTIA: A CASE THAT PROGNOSED AS SCHIZOPHRENIA-LIKE PSYCHOSIS

Psychiatry and Clinical Psychopharmacology, 2021
Frontotemporal dementia (FTD) is a common type of dementia which attracts increasingly more attention. With the advances in neuropsychological evaluations and development of clinical diagnosis criteria, it, will probably, be recognized more commonly ...
Şebnem Pırıldar, Emre Bora, Dilek Evyapan, Süha Özaşkınlı   +3 more
doaj