Results 1 to 10 of about 24,976 (233)

Genetics of Frontotemporal Lobar Degeneration [PDF]

Frontiers in Neurology, 2012
Frontotemporal Lobar Degeneration (FTLD) is the most frequent neurodegenerative disorder with a presenile onset. It presents with a spectrum of clinical manifestations, ranging from behavioural and executive impairment to language disorders and motor ...
Daniela eGalimberti, Elio eScarpini
doaj   +5 more sources

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration [PDF]

Translational Psychiatry, 2022
There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including symptomatic treatments.
Alistair Perry, Laura E. Hughes, Natalie Adams, Michelle Naessens, Alexander G. Murley, Matthew A. Rouse, Duncan Street, P. Simon Jones, Thomas E. Cope, Ece Kocagoncu, James B. Rowe   +10 more
doaj   +2 more sources

New Perspective on Parkinsonism in Frontotemporal Lobar Degeneration [PDF]

Journal of Movement Disorders, 2013
Frontotemporal dementia (FTD) is the second most common type of presenile dementia. Three clinical prototypes have been defined; behavioral variant FTD, semantic dementia, and progressive nonfluent aphasia.
Hee Kyung Park, Sun J. Chung
doaj   +2 more sources

Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B [PDF]

Annals of Clinical and Translational Neurology
Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations.
Sean Coulborn, Rhiana Schafer, Ashlin R. K. Roy, Andrzej Sokolowski, Noah G. Cryns, Dana Leichter, Argentina Lario Lago, Eliana Marisa Ramos, Yann Cobigo, Salvatore Spina, Lea T. Grinberg, Daniel H. Geschwind, Maria L. Gorno‐Tempini, Joel H. Kramer, Howard J. Rosen, Bruce L. Miller, William W. Seeley, David C. Perry   +17 more
doaj   +2 more sources

Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease [PDF]

, 2014
Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential ...
AF Fotenos, AT Du, B Dubois, BC Dickerson, Belinda Yew, Bonnie Y. K. Lam, C Bocti, C Davatzikos, C O'Callaghan, CE Krueger, CM Pleizier, D Chan, D Neary, DS Knopman, DS Yi, E Mioshi, E Mioshi, E Ratnavalli, Emma Flanagan, F Agosta, Francisco J. Esteban, G McKhann, H Hampel, Hans-Jürgen Huppertz, HJ Huppertz, HJ Rosen, J Ashburner, JC Looi, JL Whitwell, John R. Hodges, K Rascovsky, K Rascovsky, L Frings, Lars Frings, M Boccardi, M Broe, M Hornberger, M Hornberger, M Hornberger, MA Dalton, Michael Hornberger, Michael Hüll, O Piguet, P Lillo, PJ Nestor, RJ Perry, RR Davies, SM Resnick, TW Chow, WW Seeley, Y Benjamini   +50 more
core   +17 more sources

Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau

Acta Neuropathologica Communications, 2021
Alzheimer’s disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinning with antemortem optical coherence ...
Benjamin J. Kim, Vivian Lee, Edward B. Lee, Adrienne Saludades, John Q. Trojanowski, Joshua L. Dunaief, Murray Grossman, David J. Irwin   +7 more
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MicroRNA biomarkers in frontotemporal dementia and to distinguish from Alzheimer’s disease and amyotrophic lateral sclerosis

Neural Regeneration Research, 2022
Frontotemporal lobar degeneration describes a group of progressive brain disorders that primarily are associated with atrophy of the prefrontal and anterior temporal lobes.
Bridget Martinez, Philip V Peplow
doaj   +1 more source

Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration

Nature Communications, 2023
There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models ...
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe   +16 more
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Response to: Clinical Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B [PDF]

Annals of Clinical and Translational Neurology
Sergi Borrego‐Écija, Cèlia Cruz‐Escalera, Agnes Perez‐Millán, Jordi Juncà‐Parellà   +3 more
doaj   +2 more sources

The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis

Neural Regeneration Research, 2020
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are multifaceted diseases with genotypic, pathological and clinical overlap. One such overlap is the presence of SQSTM1/p62 mutations.
Adriana Delice Foster, Sarah Lyn Rea
doaj   +1 more source