Results 1 to 10 of about 30,862 (225)

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration [PDF]

Translational Psychiatry, 2022
There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including symptomatic treatments.
Alistair Perry, Laura E. Hughes, Natalie Adams, Michelle Naessens, Alexander G. Murley, Matthew A. Rouse, Duncan Street, P. Simon Jones, Thomas E. Cope, Ece Kocagoncu, James B. Rowe   +10 more
doaj   +2 more sources

Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration

Nature Communications, 2023
There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models ...
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe   +16 more
doaj   +2 more sources

Signature laminar distributions of pathology in frontotemporal lobar degeneration [PDF]

Acta Neuropathologica, 2022
Frontotemporal lobar degeneration (FTLD) with either tau (FTLD-tau) or TDP-43 (FTLD-TDP) inclusions are distinct proteinopathies that frequently cause similar frontotemporal dementia (FTD) clinical syndromes.
Daniel T. Ohm, Katheryn A Q Cousins, Sharon X. Xie, Claire Peterson, Corey T. McMillan, Lauren Massimo, Katya Raskovsky, David A. Wolk, Vivianna M. Van Deerlin, Lauren Elman, Meredith Spindler, Andres Deik, John Q. Trojanowski, Edward B. Lee, Murray Grossman, David J. Irwin   +15 more
openalex   +2 more sources

Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries [PDF]

JAMA Neurology, 2023
This cohort study analyzes age- and sex-specific incidence rates of frontotemporal lobar degeneration–related disorders by phenotype across 9 European countries.
Giancarlo Logroscino, Marco Piccininni, Caroline Graff, Orla Hardiman, Albert C. Ludolph, Fermín Moreno, Markus Otto, Anne M. Remes, James B. Rowe, Harro Seelaar, Eino Solje, Elka Stefanova, Latchezar Traykov, Vesna Jelić, Melissa Taheri Rydell, Niall Pender, Sarah Anderl‐Straub, Myriam Barandiarán, Alazne Gabilondo, Johanna Krüger, Alexander G. Murley, Timothy Rittman, Emma L. van der Ende, John C. van Swieten, Päivi Hartikainen, Gorana Mandić Stojmenović, Shima Mehrabian, Luisa Benussi, Antonella Alberici, Maria Teresa Dell’Abate, Chiara Zecca, Barbara Borroni, Diyana Belezhanska, Angelo Bianchetti, Giuliano Binetti, Maria Sofia Cotelli, Maria Sofia Cotelli, Irena Dreharova, Marco Filardi, Silvia Fostinelli, Roberta Ghidoni, Valentina Gnoni, Genoveva Nacheva, Ivana Novaković, Alessandro Padovani, Ivo D. Popivanov, Margarita Raycheva, Katherine Stockton, Katya Stoyanova, Noora‐Maria Suhonen, Mikel Tainta, Draga Toncheva, Daniele Urso, Dora Zlatareva, Miren Zulaica   +54 more
openalex   +2 more sources

Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B [PDF]

Annals of Clinical and Translational Neurology
Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations.
Sean Coulborn, Rhiana Schafer, Ashlin R. K. Roy, Andrzej Sokolowski, Noah G. Cryns, Dana Leichter, Argentina Lario Lago, Eliana Marisa Ramos, Yann Cobigo, Salvatore Spina, Lea T. Grinberg, Daniel H. Geschwind, Maria L. Gorno‐Tempini, Joel H. Kramer, Howard J. Rosen, Bruce L. Miller, William W. Seeley, David C. Perry   +17 more
doaj   +2 more sources

Neuropathology of frontotemporal lobar degeneration: A review [PDF]

Dementia & Neuropsychologia, 2013
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD)
Valéria Santoro Bahia, Leonel Tadao Takada, Vincent Deramecourt   +2 more
doaj   +2 more sources

Characterization of Movement Disorder Phenomenology in Genetically Proven, Familial Frontotemporal Lobar Degeneration: A Systematic Review and Meta-Analysis.

PLoS ONE, 2016
BackgroundMutations in granulin (PGRN) and tau (MAPT), and hexanucleotide repeat expansions near the C9orf72 genes are the most prevalent genetic causes of frontotemporal lobar degeneration.
Carmen Gasca-Salas, Mario Masellis, Edwin Khoo, Binit B Shah, David Fisman, Anthony E Lang, Galit Kleiner-Fisman   +6 more
doaj   +3 more sources

Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease [PDF]

, 2014
Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential ...
AF Fotenos, AT Du, B Dubois, BC Dickerson, Belinda Yew, Bonnie Y. K. Lam, C Bocti, C Davatzikos, C O'Callaghan, CE Krueger, CM Pleizier, D Chan, D Neary, DS Knopman, DS Yi, E Mioshi, E Mioshi, E Ratnavalli, Emma Flanagan, F Agosta, Francisco J. Esteban, G McKhann, H Hampel, Hans-Jürgen Huppertz, HJ Huppertz, HJ Rosen, J Ashburner, JC Looi, JL Whitwell, John R. Hodges, K Rascovsky, K Rascovsky, L Frings, Lars Frings, M Boccardi, M Broe, M Hornberger, M Hornberger, M Hornberger, MA Dalton, Michael Hornberger, Michael Hüll, O Piguet, P Lillo, PJ Nestor, RJ Perry, RR Davies, SM Resnick, TW Chow, WW Seeley, Y Benjamini   +50 more
core   +13 more sources

Frontotemporal lobar degeneration

Nature Reviews Disease Primers, 2023
This PrimeView highlights the mechanisms, diagnosis, epidemiology and management of frontotemporal lobar degeneration.
M. Grossman, W. Seeley, A. Boxer, A. Hillis, D. Knopman, Peter A. Ljubenov, B. Miller, O. Piguet, R. Rademakers, J. Whitwell, H. Zetterberg, J. V. van Swieten   +11 more
semanticscholar   +2 more sources

Response to: Clinical Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B [PDF]

Annals of Clinical and Translational Neurology
Sergi Borrego‐Écija, Cèlia Cruz‐Escalera, Agnes Perez‐Millán, Jordi Juncà‐Parellà   +3 more
doaj   +2 more sources