Results 21 to 30 of about 30,886 (249)

HnRNP Pathologies in Frontotemporal Lobar Degeneration

Cells, 2023
Frontotemporal dementia (FTD) is the second most common form of young-onset (
Xinwa Jiang, Ariana Gatt, Tammaryn Lashley   +2 more
doaj   +1 more source

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

Nature Medicine, 2020
With the potential development of new disease-modifying Alzheimer’s disease (AD) therapies, simple, widely available screening tests are needed to identify which individuals, who are experiencing symptoms of cognitive or behavioral decline, should be ...
Elisabeth H Thijssen, R. La Joie, Amy Wolf, Amelia Strom, Ping Wang, Leonardo Iaccarino, Viktoriya Bourakova, Y. Cobigo, H. Heuer, S. Spina, L. Vandevrede, Xiyun Chai, Nicholas K. Proctor, D. Airey, S. Shcherbinin, C. Duggan Evans, J. Sims, H. Zetterberg, K. Blennow, A. Karydas, C. Teunissen, J. Kramer, L. Grinberg, W. Seeley, H. Rosen, B. Boeve, B. Miller, G. Rabinovici, J. Dage, J. Rojas, A. Boxer, Leah David S. Neill Murray Edward H. Chiadi Daniel Erik Forsberg Knopman Graff-Radford Grossman Huey Onyik, L. Forsberg, D. Knopman, N. Graff-Radford, M. Grossman, Edward Huey, C. Onyike, D. Kaufer, E. Roberson, N. Ghoshal, S. Weintraub, B. Appleby, I. Litvan, D. Kerwin, M. Mendez, Y. Bordelon, G. Coppola, E. Ramos, M. Tartaglia, G. Hsiung, I. Mackenzie, K. Domoto-Reilly, T. Foroud, B. Dickerson   +54 more
semanticscholar   +1 more source

HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing

Acta Neuropathologica, 2021
Heterogeneous nuclear ribonucleoproteins (HnRNPs) are a group of ubiquitously expressed RNA-binding proteins implicated in the regulation of all aspects of nucleic acid metabolism. HnRNP K is a member of this highly versatile hnRNP family.
A. Bampton, A. Gatt, J. Humphrey, S. Cappelli, Dipanjan Bhattacharya, S. Foti, Anna L. Brown, Y. Asi, Yi-Hua Low, M. Foiani, T. Raj, E. Buratti, P. Fratta, T. Lashley   +13 more
semanticscholar   +1 more source

GABAergic cortical network physiology in frontotemporal lobar degeneration

Brain : a journal of neurology, 2021
The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous, including the behavioural variant frontotemporal dementia (bvFTD) and progressive supranuclear palsy.
N. Adams, L. Hughes, M. Rouse, Holly N. Phillips, A. Shaw, A. Murley, T. Cope, W. R. Bevan-Jones, L. Passamonti, D. Street, N. Holland, D. Nesbitt, Karl J. Friston, J. Rowe   +13 more
semanticscholar   +1 more source

Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration

Frontiers in Neuroscience, 2019
ObjectiveWhile Alzheimer’s disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (SD-OCT), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (FTD ...
Benjamin J. Kim, Murray Grossman, Delu Song, Samantha Saludades, Wei Pan, Sophia Dominguez-Perez, Joshua L. Dunaief, Tomas S. Aleman, Gui-Shuang Ying, David J. Irwin   +9 more
doaj   +1 more source

A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration. [PDF]

PLoS ONE, 2013
The transactive response DNA-binding protein (TDP-43) is a major component of the abnormal intracellular inclusions that occur in two common neurodegenerative diseases of humans: (1) a subtype of frontotemporal lobar degeneration and (2) amyotrophic ...
Patrick J Bosque, Philip J Boyer, Priya Mishra   +2 more
doaj   +1 more source

New Perspective on Parkinsonism in Frontotemporal Lobar Degeneration [PDF]

Journal of Movement Disorders, 2013
Frontotemporal dementia (FTD) is the second most common type of presenile dementia. Three clinical prototypes have been defined; behavioral variant FTD, semantic dementia, and progressive nonfluent aphasia.
Hee Kyung Park, Sun J. Chung
doaj   +1 more source

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by ...
Pasinelli, Piera, Trotti, Davide, Wen, Xinmei, Westergard, Thomas   +3 more
core   +2 more sources

Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology

Acta Neuropathologica Communications, 2021
Frontotemporal lobar degeneration proteinopathies with tau inclusions (FTLD-Tau) or TDP-43 inclusions (FTLD-TDP) are associated with clinically similar phenotypes.
Lucia A. A. Giannini, Claire S. Peterson, D. Ohm, S. Xie, C. Mcmillan, Katya Raskovsky, L. Massimo, E. Suh, V. V. Van Deerlin, D. Wolk, J. Trojanowski, Eddie B. Lee, M. Grossman, D. Irwin   +13 more
semanticscholar   +1 more source

Pharmacological treatment of frontotemporal lobar degeneration: systematic review Tratamento farmacológico da degeneração lobar frontotemporal: revisão sistemática

Brazilian Journal of Psychiatry, 2011
OBJECTIVE: To identify the therapeutic options available for treatment of cognitive and behavioral symptoms in frontotemporal lobar degeneration. METHOD: Systematic review using the descriptors "frontotemporal lobar degeneration" OR "frontotemporal ...
Maria da Glória Portugal, Valeska Marinho, Jerson Laks   +2 more
doaj   +1 more source