Results 91 to 100 of about 671,731 (301)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Ring particle sizes and composition derived from eclipse cooling curves and reflection spectra [PDF]
The probable chemistry of the Saturn rings is reviewed. Reflectance spectra for H20 and NH3 frosts and Saturn's rings are compared, along with temperature dependence of 1.6 microns water frost feature.
Kieffer, H. H.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A subpopulation of projections from the parabrachial nucleus to the central amygdala mediates itch
Scientific ReportsThe parabrachial nucleus (PBN) plays a crucial role in transmitting itch and affective pain signals to the brain regions such as the central amygdala (CeA).
Darya Pavlenko +3 more
doaj +1 more source
Reducing Able-bodied Entitlement: The Effects of Education, Privilege Acknowledgment, and Inter-group Contact [PDF]
, 2018 Too often, socially privileged individuals act in ways that display entitlement, ignorance, or disregard for marginalized people, even when they are educated about the dynamics of oppression and privilege. Because education alone may not be sufficient to
Frost, Remy
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
UTSI atmospheric science program [PDF]
, 1977 Two areas of research were carried out concerned with meteorological and environmental inputs to aviation systems. One effort dealt with the investigation of wind fields about bluff geometries typical of buildings or other man made obstructions to the ...
Frost, W.
core +1 more source