Results 121 to 130 of about 672,406 (301)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Performance of a hypersonic hot fuselage structure with a carbon dioxide frost projected, nonintegral cryogenic tank [PDF]
A model which consisted of a hot structure and a nonintegral tank protected by a carbon dioxide frost thermal protection system was tested under the following conditions: (1) room temperature loading and (2) heating and loading corresponding to the Mach ...
Jackson, L. R., Sharpe, E. L.
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
High sensitivity of herbaceous legumes to freezing: Insights from a multiyear snow removal study
EcosphereReductions in snow cover resulting from winter climate change are anticipated to increase the intensity of freezing exposure for overwintering herbaceous plants in many northern temperate regions.
Samuel L. Rycroft, Hugh A. L. Henry
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Experimental Investigation on Frost Formation on Cold Surface under Natural Convection Conditions
Zhileng xuebao, 2019 A microscopic visualization method was applied experimentally, where comparative observations of frosting processes were conductedunder the same conditionson bare aluminum and hydrophobic surface with contact angles of 78° and 141°, respectively.
Zhou Shengqi +3 more
doaj
Analysis of different frost indexes and their potential to assess frost based on HAM simulations [PDF]
, 2017 To reach the climate goals of 2020 our buildings have to become a lot more energy-efficient. This challenge rests mainly on the shoulders of the renovation sector because new buildings are only a small part of our building stock.
Calle, Klaas, Van Den Bossche, Nathan
core