Results 61 to 70 of about 671,731 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Retrospective Analysis of Itch Intensity and Comorbidities in Lichen Simplex Chronicus

Acta Dermato-Venereologica
Lichen simplex chronicus is a chronic pruritic skin condition that significantly impacts quality of life. This retrospective study analysed 125 patients with clinically confirmed lichen simplex chronicus seen at a tertiary academic centre to characterize
Kayla D. Mashoudy, Joselyn Ye-Tay, Sarah Kim, Nicole Khalil, Gil Yosipovitch   +4 more
doaj   +1 more source

The control of carbon dioxide cryodeposits [PDF]

An experimental study has been conducted to investigate the parameters affecting the cryodeposition of carbon dioxide frost. In the investigation carbon dioxide frost was cryodeposited from a helium-carbon dioxide mixture into a layer of fibrous ...
Sharpe, E. L.
core   +1 more source

Concrete Pavement Mixture Design and Analysis (MDA): Assessment of Air Void System Requirements for Durable Concrete, TPF-5(205), 2012 [PDF]

, 2012
Concrete will suffer frost damage when saturated and subjected to freezing temperatures. Frost-durable concrete can be produced if a specialized surfactant, also known as an air-entraining admixture (AEA), is added during mixing to stabilize microscopic ...

core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Novel Topical Treatments for Itch

Dermatology and Therapy
The experience of itch often poses a burden on patient quality of life and has the capacity to inflict significant suffering. Topical therapies are a mainstay of treatment for many cutaneous and systemic diseases and afford patients the opportunity to ...
Rami H. Mahmoud, Omar Mahmoud, Georgia Biazus Soares, Gil Yosipovitch   +3 more
doaj   +1 more source

Impact of Multiple Ecological Stressors on a Sub-Arctic Ecosystem: No Interaction Between Extreme Winter Warming Events, Nitrogen Addition and Grazing

Frontiers in Plant Science, 2018
Climate change is one of many ongoing human-induced environmental changes, but few studies consider interactive effects between multiple anthropogenic disturbances.
Stef Bokhorst, Stef Bokhorst, Matty P. Berg, Matty P. Berg, Guro K. Edvinsen, Jacintha Ellers, Amber Heitman, Laura Jaakola, Laura Jaakola, Hanne K. Mæhre, Gareth K. Phoenix, Hans Tømmervik, Jarle W. Bjerke   +12 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Estimating Frost during Growing Season and Its Impact on the Velocity of Vegetation Greenup and Withering in Northeast China

Remote Sensing, 2020
Vegetation phenology and photosynthetic primary production have changed simultaneously over the past three decades, thus impacting the velocity of vegetation greenup (Vgreenup) and withering (Vwithering). Although climate warming reduces the frequency of
Guorong Deng, Hongyan Zhang, Lingbin Yang, Jianjun Zhao, Xiaoyi Guo, Hong Ying, Wu Rihan, Dan Guo   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source