Results 61 to 70 of about 672,406 (301)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Botulinum Toxin in the Treatment of Hair and Scalp Disorders: Current Evidence and Clinical Applications

Toxins
Botulinum toxin (BoNT) is well-recognized throughout dermatology for its cosmetic indications and growing therapeutic value. Recent studies have trialed BoNT in the treatment of hair and scalp disorders, many of which lack long-term effective treatments ...
Sofia M. Perez, Sarah A. AlSalman, Betty Nguyen, Antonella Tosti   +3 more
doaj   +1 more source

Intercalation of Hydrotalcites with Hexacyanoferrate(II) and (III)-a ThermoRaman Spectroscopic Study [PDF]

, 2005
Raman spectroscopy using a hot stage indicates that the intercalation of hexacyanoferrate(II) and (III) in the interlayer space of a Mg,Al hydrotalcites leads to layered solids where the intercalated species is both hexacyanoferrate(II) and (III).
Anthony W. Musumeci, Bish, Braterman, Carpani, Crespo, Fernandez, Ferreira, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost Ray, Hansen, Hansen, Hickey, Holgado, Horvath, Horvath, Idemura, Iglesias, Itaya, J. Theo Kloprogge, Jocelyn Bouzaid, Johnson, Kikkawa, Kloprogge, Kloprogge, Kloprogge, Kristof, Labuda, Lichti, Moses O. Adebajo, Nickel, Okada, Ray L. Frost, Rey, Roh, Seida, Seida, Shaw, Taylor, Taylor, Valcheva-Traykova, Wayde N. Martens, Yao, Yao   +49 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Impact of Multiple Ecological Stressors on a Sub-Arctic Ecosystem: No Interaction Between Extreme Winter Warming Events, Nitrogen Addition and Grazing

Frontiers in Plant Science, 2018
Climate change is one of many ongoing human-induced environmental changes, but few studies consider interactive effects between multiple anthropogenic disturbances.
Stef Bokhorst, Stef Bokhorst, Matty P. Berg, Matty P. Berg, Guro K. Edvinsen, Jacintha Ellers, Amber Heitman, Laura Jaakola, Laura Jaakola, Hanne K. Mæhre, Gareth K. Phoenix, Hans Tømmervik, Jarle W. Bjerke   +12 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Uremic frost [PDF]

Clinical Kidney Journal, 2014
Mathur, Mohit, D'Souza, Amith V.L., Malhotra, Vinay, Agarwal, Dhananjai, Beniwal, Pankaj   +4 more
openaire   +5 more sources

Novel Topical Treatments for Itch

Dermatology and Therapy
The experience of itch often poses a burden on patient quality of life and has the capacity to inflict significant suffering. Topical therapies are a mainstay of treatment for many cutaneous and systemic diseases and afford patients the opportunity to ...
Rami H. Mahmoud, Omar Mahmoud, Georgia Biazus Soares, Gil Yosipovitch   +3 more
doaj   +1 more source

Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery

JID Innovations
Owing to the increasingly high volume of cutaneous and percutaneous procedures performed annually, the demand for local anesthesia has steadily risen. The gold-standard formulations for local anesthesia contain epinephrine at a concentration of 1:100,000
Joanna Dong, Naiem T. Issa, Michael Kaiser, Simonetta I. Gaumond, Michael Solis, Joel Gil, Robert S. Kirsner, Stephen C. Davis, Joaquin J. Jimenez   +8 more
doaj   +1 more source