Results 191 to 200 of about 2,389,697 (294)

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

open access: yesClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong   +6 more
wiley   +1 more source

Rooftop Breeding Does Not Consistently Explain Variation in Yolk Testosterone in Herring Gulls

open access: yesEcology and Evolution, Volume 16, Issue 9, September 2026.
Rooftop‐ and ground‐breeding represent distinct ecological contexts that may influence maternal hormone allocation in Herring gulls. Yolk testosterone concentrations differed between rooftop‐ and ground‐breeding pairs in one of 2 years but were not consistently associated with breeding context, nest density or proxies of maternal quality, suggesting ...
Jolien Van Malderen   +4 more
wiley   +1 more source

Navigating Human Astrocyte Differentiation: Direct and Rapid One‐Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development

open access: yesGlia, Volume 74, Issue 9, September 2026.
One‐step protocol enabling direct differentiation of human iPSCs into functional astrocytes within 5 weeks. Validated in > 60 lines across 10 labs. iPSC‐astrocytes support robust neuronal network development in co‐culture. ABSTRACT Astrocytes play a pivotal role in neuronal network development.
Imke M. E. Schuurmans   +39 more
wiley   +1 more source

Antioxidant‐Thermoresponsive Collagen/Chitosan Nanocomposite Hydrogels With Praseodymium‐Doped Mesoporous Bioglass for Enhanced Bone Regeneration

open access: yesJournal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.
ABSTRACT Oxidative stress is a critical barrier to effective bone regeneration, often impairing cellular function and osteogenic differentiation. In this study, we report the novel development of a multifunctional chitosan/collagen (CS/Coll) hydrogel integrated with praseodymium‐doped mesoporous bioactive glass nanoparticles (Pr‐MBGNs) engineered for ...
Kulwinder Kaur   +3 more
wiley   +1 more source

Proteo‐Metabolomic Profiling of PMM2‐CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo‐Inositol, and the Hexosamine Pathway

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Diana Gallego   +10 more
wiley   +1 more source

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