ABSTRACT Introduction Preimplantation genetic testing for monogenic diseases (PGT‐M) is a reproductive option for couples at high risk of transmitting inherited disorders. We report a ten‐year single‐centre PGT‐M experience in families at risk of hemophilia.
Mimosa Mortarino +6 more
wiley +1 more source
Authors' Response to the Commentary on "Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy". [PDF]
Ito A, Sekiguchi M, Katagiri Y.
europepmc +1 more source
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo +7 more
wiley +1 more source
Enhancing frozen-thawed embryo transfer outcomes and treatment personalization through machine learning models. [PDF]
Li J +8 more
europepmc +1 more source
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang +7 more
wiley +1 more source
Anxiety and depression in recurrent implantation failure after frozen-thawed embryo transfer and efficacy of endometrial receptivity testing. [PDF]
Guo YB, Tang B, Zhang L, Wu X, Huang ZH.
europepmc +1 more source
AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ‐Secretase Assembly
AHA1 regulates Aβ production through dual mechanisms. AHA1 promotes APP abundance through mechanisms that are at least partially independent of Hsp90 interaction, while cooperating with Hsp90 to regulate APH1/NCT pre‐complex formation, γ‐secretase assembly, and γ‐secretase activity. These coordinated mechanisms contribute to increased Aβ generation and
Arshad Ali Noorani +9 more
wiley +1 more source
PsORP1 anchors ER–Golgi MCSs to mediate PS/PI4P counter‐transport, and oxathiapiprolin targets the ORD to inhibit this lipid exchange. ABSTRACT Oxysterol‐binding protein (OSBP)‐related proteins (ORPs) are indispensable eukaryotic lipid transporters and promising targets for pharmaceutical and agrochemical exploitation.
Xiaofei Liu +6 more
wiley +1 more source
The relationship between vaginal and endometrial microbiota and the outcome of Frozen-Thawed embryo transfer during hormone replacement cycles. [PDF]
Chen L, Ke Y, Guo H, Wu B, Liu L.
europepmc +1 more source
Fish Sperm Subpopulations Detection, Separation, and Application: Current State and Trends
Modern advances in sperm biology highlight the necessity of recognising intra‐ejaculate heterogeneity as a central concept for advancing both the fundamental understanding of fertilisation processes and the development of artificial reproduction techniques in fishes. ABSTRACT Sperm subpopulations represent a fundamental manifestation of intra‐ejaculate
Viktoriya Dzyuba +2 more
wiley +1 more source

