Results 61 to 70 of about 294,648 (305)

ANGPTL3 orchestrates hepatic fructose sensing and metabolism

Cell Reports
Summary: Fructose metabolism is linked to metabolic dysfunction-associated steatotic liver disease (MASLD), but the regulatory mechanisms governing fructose uptake remain poorly understood.
Meng Zhao, Karen Y. Linde-Garelli, Zeyuan Zhang, David Toomer, Saranya C. Reghupaty, John Isaiah Jimenez, Laetitia Coassolo, Lianna W. Wat, Daniel Fernandez, Katrin J. Svensson   +9 more
doaj   +1 more source

Development of tools to facilitate the diagnosis of hereditary fructose intolerance

JIMD Reports, 2023
Although hereditary fructose intolerance (HFI) is an inborn error of fructose metabolism that classically presents at infancy, the diagnosis is often missed or delayed. In this study, we aimed to develop tools to facilitate the diagnosis of HFI.
Bianca Panis, Lise E. F. Janssen, Dirk J. Lefeber, Nynke Simons, M. Estela Rubio‐Gozalbo, Martijn C. G. J. Brouwers   +5 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis

Journal of Obesity, 2014
The consumption of artificially sweetened processed foods, particularly high in fructose or high fructose corn syrup, has increased significantly in the past few decades.
Deborah M. Sloboda, Minglan Li, Rachna Patel, Zoe E. Clayton, Cassandra Yap, Mark H. Vickers   +5 more
doaj   +1 more source

DIFFERENT ACUTE METABOLISM OF FRUCTOSE IN DIALYSIS PATIENTS COMPARED TO HEALTHY SUBJECTS

Kidney Research and Clinical Practice, 2012
The consumption of fructose has increased dramatically during the last two decades and parallels the epidemics of obesity, metabolic syndrome, diabetes and chronic kidney disease ADDIN EN.CITE ADDIN EN.CITE.DATA . Fructose comes naturally e.g.
Björn Anderstam, Ann-Christin Bragfors-Helin, Jonas Axelsson, Abdul Rashid Qureshi, Rolf Wibom, Bengt Lindholm, Peter Stenvinkel   +6 more
doaj   +1 more source

Observations on the water distribution and extractable sugar content in carrot slices after pulsed electric field treatment [PDF]

, 2014
peer-reviewedThe impact of pulsed electric field (PEF) processing conditions on the distribution of water in carrot tissue and extractability of soluble sugars from carrot slices was studied.
Aguilo-Aguayo, Ingrid, Brunton, Nigel, Downey, Gerard, Keenan, Derek F., Lyng, James G., Rai, Dilip K.   +5 more
core   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Saccharomyces cerevisiae in the production of fermented beverages [PDF]

, 2016
Alcoholic beverages are produced following the fermentation of sugars by yeasts, mainly (but not exclusively) strains of the species, Saccharomyces cerevisiae.
Stewart, Graham G., Walker, Graeme M.
core   +4 more sources

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

Fructose malabsorption and fructan malabsorption are associated in patients with irritable bowel syndrome

BMC Gastroenterology
Background Food malabsorption and intolerance is implicated in gastrointestinal symptoms among patients with irritable bowel syndrome (IBS). Key triggers include fructose and fructan.
Twan Sia, Riki O. Tanaka, Albert Mousad, Aditya P. Narayan, Kristen Si, Leeon Bacchus, Hind Ouerghi, Aashka Patel, Arnav Patel, Evan Cunningham, Taylor Epstein, Jerry Fu, Stanley Liu, Raisa Khuda, Paige McDonald, Shibani Mallik, Joanna McNulty, Michelle Pan, John Leung   +18 more
doaj   +1 more source