Results 191 to 200 of about 43,945 (264)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Trade-Offs Between Fruit Health, Oil Accumulation, and Bioactive Retention During Olive Fruit Ripening in Four Spanish Olive Cultivars. [PDF]

Foods
Martínez-Cañas MA, González-Trejo A, Manai-Djebali H, Cortés-Montaña D.   +3 more
europepmc   +1 more source

Integrated transcriptomic and metabolomic analyses elucidate the regulatory role of SlBEL11 in tomato fruit ripening. [PDF]

Front Plant Sci
Dong X, Lu J, Guo Y, Zhang Q, Yang Q, Peng J, Tian L.   +6 more
europepmc   +1 more source

‘It's all very well having a diverse curriculum, but if there is no curriculum, it can be as diverse as you like’: Precarity and decolonising in the neoliberal UK higher education system

British Educational Research Journal, EarlyView.
Abstract Drawing upon interview research across two academic departments as part of the early stages of a ‘decolonise the curriculum’ initiative at a Southern UK university, this study highlights a growing gulf between policy and practice in efforts to address systemic racial inequalities in UK universities. A reliance upon precarious labour, a culture
Triona Fitton, Barbara Adewumi, Laura R. Bailey, Jacob W. Moore, Lauren‐Marie Aba Amoah   +4 more
wiley   +1 more source

Red LED light accelerates capsanthin accumulation and fruit ripening in pre-harvest pepper (<i>Capsicum annuum</i> L.). [PDF]

Front Plant Sci
Mao P, Yang Q, Yang T, Zou P, Zheng Y.
europepmc   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

The triggering mechanism for predominant hormonal signal production in fleshy fruit ripening. [PDF]

Mol Hortic
Ouyang J, He B, Zeng Y, Zhai C, Li Y, Li J, Guan P, Jia W.   +7 more
europepmc   +1 more source

How wildlife respond to tropical cyclones: short‐term tactics and long‐term impacts

Biological Reviews, EarlyView.
ABSTRACT From butterflies to lizards and from sharks to seabirds, wildlife exhibit tactics to survive the impacts of tropical cyclones, also known as hurricanes, cyclones, or typhoons depending on where they occur. Some species seek refuge during the storm by moving, some remain in place and ride it out, and others move longer distances, avoiding the ...
Erin L. Koen, Mohamed Khalil Meliane, Zachery B. Holmes, Karl E. Miller, William J. Barichivich, Emilie Dedeban, Alex Furst, Miranda Imeri, Peyton E. Niebanck, Samantha Nunn, Kailee Pearson, Nicole Rita, Brier Ryver, Dakotah Shaffer, Susan C. Walls, E. Hance Ellington   +15 more
wiley   +1 more source

Activation of alternative oxidase ensures carbon supply for ethylene and carotenoid biosynthesis during tomato fruit ripening. [PDF]

Plant Physiol
Iglesias-Sanchez A, Del-Saz NF, Ezquerro M, Feixes-Prats E, Ribas-Carbo M, Fernie AR, Rodríguez-Concepción M, Florez-Sarasa I.   +7 more
europepmc   +1 more source

Orchard netting impacts on biodiversity leading to cascading effects at the ecosystem level

Biological Reviews, EarlyView.
ABSTRACT Agriculture must ensure food production without further compromising the ecosystem functions upon which it depends. Agricultural practices should therefore avoid harming farmland biodiversity, especially of taxa that supply the key ecosystem services (e.g.
Corrado Alessandrini, Karan Sethi, Emanuela Granata, Ekaterina Mogilnaia, Valeria Vitangeli, Giovanni Zanfei, Chiara Fedrigotti, Paolo Biella, Dino Scaravelli, Luigi Marchesi, Péter Batáry, Diego Rubolini, Paolo Pedrini, Mattia Brambilla   +13 more
wiley   +1 more source