Results 1 to 10 of about 12,619 (254)

Comprehensive Analysis of PAPPA2 Expression and Genetic Variants in Sheep and Their Association With Litter Size

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
ABSTRACT Background The PAPPA2 gene encodes a metalloproteinase critical for regulating insulin‐like growth factor (IGF) bioavailability through cleavage of insulin‐like growth factor‐binding protein 5 (IGFBP5). While its role in human and murine reproduction is documented, its function in sheep reproductive traits remains underexplored. Objective This
Yuanyuan Wang, Wenqiang Xu, Benmeng Liang, Shujing Li, Wenping Hu, Mingxing Chu   +5 more
wiley   +1 more source

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]

, 2009
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H., Baker, P.J., Huhtaniemi, I., Morris, I.D., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Spatial Transcriptomic Characteristics of the Aging Human Ovary

Aging Cell, Volume 25, Issue 1, January 2026.
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang, Fanghao Guo, Qing Zhang, Qianhui Hu, Di Sun, Yongjian Ma, Yanquan Li, Mengxi Guo, Haixia Ding, Ying Guo, Baicai Yang, Songmao Li, Ningxia Sun, Yuxuan Zheng, Wen Li   +14 more
wiley   +1 more source

A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy

JCI Insight, 2022
Despite advances in ovarian cancer (OC) therapy, recurrent OC remains a poor-prognosis disease. Because of the close interaction between OC cells and the tumor microenvironment (TME), it is important to develop strategies that target tumor cells and ...
Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O’Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang, David B. Weiner   +10 more
doaj   +1 more source

A Spatial Simulation Approach to Account for Protein Structure When Identifying Non-Random Somatic Mutations [PDF]

, 2013
Background: Current research suggests that a small set of "driver" mutations are responsible for tumorigenesis while a larger body of "passenger" mutations occurs in the tumor but does not progress the disease.
Bjornson, Robert, Cheng, Yuwei, Cheung, Kei-Hoi, Modis, Yorgo, Ryslik, Gregory, Zelterman, Daniel, Zhao, Hongyu   +6 more
core   +2 more sources

Humanized Mouse Models as a Cellular Platform for Investigating Immune‐Hormonal Crosstalk and Therapeutic Strategies in Menopause

Aging Cell, Volume 25, Issue 1, January 2026.
Humanized mice offer new insight into immune‐hormonal changes during menopause. Traditional models lack accuracy in replicating human menopause physiology. Functional foods may ease symptoms but need testing in human‐relevant systems. Combining humanized mice with diet research can improve women's health outcomes.
Nisansala Chandimali, Jaehoon Bae, Sun Hee Cheong, Seon Gyeong Bak, Yeon‐Yong Kim, Ji‐Su Kim, Seung‐Jae Lee   +6 more
wiley   +1 more source

Analysis of interfacial shrinkage stresses in patch repairs [PDF]

, 2004
This paper presents simple analytical expressions that predict the interfacial shrinkage stresses in a repair patch over time. Four repair materials (L2, L3, L4 and G1) were applied by spraying (gunite) to unpropped compression members of two highway ...
Bennison P., British Standards Institution, British Standards Institution, F. J. O'Flaherty, Mosley W. H., P. S. Mangat, Rahman M. K.   +6 more
core   +1 more source

Ovarian Aging: A Multifaceted Perspective on Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
A mechanistic network of ovarian aging, highlighting mitochondrial dysfunction as a central hub interconnected with genetic, metabolic, and inflammatory pathways.
Xiaoqing Zhang, Xinyi Dong, Xue Zhang, Suying Yuan, Qiran Zhang, Zilu Guo, Xiaoxue Yang, Qionghua Wang, Tianlan Yang, Donghui Huang   +9 more
wiley   +1 more source

AreFSHRpolymorphisms risk factors to premature ovarian insufficiency?

Gynecological Endocrinology, 2015
Premature ovarian insufficiency (POI) is an ovarian dysfunction characterized by increased FSH levels and amenorrhea before 40 years old. In recent years, the search for genetic causes of POI intensified and studies have been published relating the presence of mutations and polymorphisms in genes associated with development, recruitment and oocyte ...
Emerson Barchi, Cordts, Monise Castro, Santos, Bianca, Bianco, Caio Parente, Barbosa, Denise Maria, Christofolini   +4 more
openaire   +2 more sources

Cell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission.

PLoS Genetics
Modulation of neurotransmission is key for organismal responses to varying physiological contexts such as during infection, injury, or other stresses, as well as in learning and memory and for sensory adaptation. Roles for cell autonomous neuromodulatory
Morgan Buckley, William P Jacob, Letitia Bortey, Makenzi E McClain, Alyssa L Ritter, Amy Godfrey, Allyson S Munneke, Shankar Ramachandran, Signe Kenis, Julie C Kolnik, Sarah Olofsson, Milica Nenadovich, Tanner Kutoloski, Lillian Rademacher, Alexandra Alva, Olivia Heinecke, Ryan Adkins, Shums Parkar, Reesha Bhagat, Jaelin Lunato, Isabel Beets, Michael M Francis, Jennifer R Kowalski   +22 more
doaj   +1 more source