Biased Signaling and Allosteric Modulation at the FSHR [PDF]
Frontiers in Endocrinology, 2019 Knowledge on G protein-coupled receptor (GPCRs) structure and mechanism of activation has profoundly evolved over the past years. The way drugs targeting this family of receptors are discovered and used has also changed.
Romain Yvinec +2 more
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Atlas of Fshr expression from novel reporter mice [PDF]
eLifeThe FSH-FSHR pathway has been considered an essential regulator in reproductive development and fertility. But there has been emerging evidence of FSHR expression in extragonadal organs.
Hongqian Chen +10 more
doaj +4 more sources
Extragonadal FSHR Expression and Function—Is It Real? [PDF]
Frontiers in Endocrinology, 2019 Expression of the follicle-stimulating hormone receptor (FSHR), besides gonadal tissues, has recently been detected in several extragonadal normal and tumorous tissues, including different types of primary and metastatic cancer and tumor vessel ...
Donata Ponikwicka-Tyszko +2 more
exaly +7 more sources
FSH stimulates lipid biosynthesis in chicken adipose tissue by upregulating the expression of its receptor FSHR [PDF]
Journal of Lipid Research, 2012 Transcripts and protein for follicle-stimulating hormone receptor (FSHR) were demonstrated in abdominal adipose tissue of female chickens. There was no expression of the Fsh gene, but FSH and FSHR colocalized, suggesting that FSH was receptor bound ...
Guiping Zhao, Jie Wen
exaly +4 more sources
Inadequate detection of the FSHR complicates future research on extragonadal FSHR localization
Frontiers in Endocrinology, 2023 IntroductionRecently, follicle stimulating hormone (FSH) through interaction with its receptor (FSHR) has been proposed to play a role in postmenopausal osteoporosis and cardiovascular disease, rather than the loss of estrogen. To explore this hypothesis,
Victoria N. Tedjawirja +5 more
doaj +4 more sources
Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling [PDF]
Frontiers in Endocrinology, 2021 Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than
Uchechukwu T. Agwuegbo +5 more
doaj +6 more sources
Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate [PDF]
Molecular MedicineBackground Extragonadal follicle-stimulating hormone (FSH) receptor (FSHR) expression in various cancers and their endothelial vessel cells has highlighted novel opportunities for targeted FSHR therapy.
Nafis A. Rahman +15 more
doaj +2 more sources
Differential Expression of LHR and FSHR in Canine Mammary Tumors: Correlation with Malignancy and Spay Status [PDF]
Veterinary SciencesCanine mammary tumors (CMTs) constitute one of the most prevalent malignancies in female canines, whereas the functional involvement of gonadotropin receptors—luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR)—in these ...
Yujue Li +8 more
doaj +2 more sources
Indian Journal of Endocrinology and Metabolism, 2021 Background: Polycystic ovarian syndrome (PCOS) is typically characterized by a spectrum of manifestations that include menstrual irregularities, anovulation, cysts, hyperandrogenic features like hirsutism, acne, alopecia, and various metabolic ...
Balaji Ramanathan +2 more
doaj +1 more source
Atenolol increases dental mineralization in male offspring of treated hypertensive rats and normotensive rats [PDF]
Brazilian Oral Research, 2020 This study evaluates how atenolol affects dental mineralization in offspring of female spontaneously hypertensive rats (fSHR) and normotensive Wistar rats (fW). fSHR and fW were treated with atenolol (100 mg/Kg/day, orally) during pregnancy and lactation.
Gracieli Prado ELIAS +4 more
doaj +1 more source