Results 61 to 70 of about 12,619 (254)

The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]

, 2019
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A, Kauffman, Alexander S   +1 more
core   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Molecular and functional insights into gonadotropin hormone receptor dimerization and oligomerization [PDF]

, 2018
The gonadotrophin hormones, follicle stimulating hormone and luteinising hormone, are essential for reproduction. They work in concert to control multiple aspects of gonadal function to ultimately produce meiotically competent and fertilisable gametes ...
Agwuegbo, U, Jonas, KC
core   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets

Nature Communications, 2023
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play important roles in extragonadal tissue.
Yi Cheng, Hong Zhu, Jun Ren, Hai-Yan Wu, Jia-En Yu, Lu-Yang Jin, Hai-Yan Pang, Hai-Tao Pan, Si-Si Luo, Jing Yan, Kai-Xuan Dong, Long-Yun Ye, Cheng-Liang Zhou, Jie-Xue Pan, Zhuo-Xian Meng, Ting Yu, Li Jin, Xian-Hua Lin, Yan-Ting Wu, Hong-Bo Yang, Xin-Mei Liu, Jian-Zhong Sheng, Guo-Lian Ding, He-Feng Huang   +23 more
doaj   +1 more source

The Role of Endocrine G Protein-Coupled Receptors in Ovarian Cancer Progression [PDF]

, 2017
published_or_final_versio
Chow, BKC, Lee, LTO, Madden, NE, Wong, AST, Zhang, Q   +4 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Association between cumulus cells—mRNA levels of AMHR2 and FSHR with oocyte maturity

Middle East Fertility Society Journal, 2022
Background The gene expression of anti-Mullerian hormone receptor type 2 (AMHR2) and follicle stimulating hormone receptor (FSHR) in cumulus cells (CCs) isolated from mature and immature oocytes was studied as a possible non-invasive approach for ...
Fateme Montazeri, Seyed Mehdi Kalantar, Farzaneh Fesahat, Mohammad Hasan Sheikhha, Marjan Omidi, Hanieh Shafienia, Seyed Mehdi Hoseini   +6 more
doaj   +1 more source

The Conserved G-Protein Coupled Receptor FSHR-1 Regulates Protective Host Responses to Infection and Oxidative Stress

, 2015
The innate immune system’s ability to sense an infection is critical so that it can rapidly respond if pathogenic microorganisms threaten the host, but otherwise maintain a quiescent baseline state to avoid causing damage to the host or to commensal ...
Giannini, Jennifer A., Grandi, Leah N., Miller, Elizabeth V., Powell, Jennifer R., Robinson, Joseph D.   +4 more
core   +3 more sources

A simplified design approach to prevent shrinkage cracking in patch repairs [PDF]

, 2006
This paper outlines two procedures for determining the interfacial shrinkage stresses in a repair patch. The first is an analytical approach based on the analogy of a bimetallic strip undergoing contraction (shrinkage).
American Society for Testing Materials, Australian Standard, British Standards Institution, Dector M. H., Emmons P. H., F. J. O'Flaherty, Hanson J. A., Illston J. M., O'Flaherty F. J., P. S. Mangat, Yuan Y. S.   +10 more
core   +1 more source