iScience, 2020 Summary: Classically, follicle-stimulating hormone receptor (FSHR)-driven cAMP-mediated signaling boosts human ovarian follicle growth and oocyte maturation.
Livio Casarini +25 more
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Onset and Heterogeneity of Responsiveness to FSH in Mouse Preantral Follicles in Culture [PDF]
, 2016 The obligatory role of follicle-stimulating hormone (FSH) in normal development and function of ovarian antral follicles is well recognized, but its function in preantral growth is less clear. The specific objective of this study was to investigate the
Fenwick, M. +5 more
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Frontiers in Cell and Developmental Biology, 2016 Posttranslational modifications occurring during the biosynthesis of G protein-coupled receptors include glycosylation and palmitoylation at conserved cysteine residues located in the carboxyl-terminus (Ctail) of the receptor.
Brenda Melo-Nava +10 more
doaj +1 more source
Molecular dynamics simulation of the follicle-stimulating hormone receptor. Understanding the conformational dynamics of receptor variants at positions N680 and D408 from in silico analysis. [PDF]
PLoS ONE, 2018 Follicle-stimulating hormone receptor (FSHR) is a G-protein coupled receptor (GPCR) and a prototype of the glycoprotein hormone receptors subfamily of GPCRs.
Eduardo Jardón-Valadez +5 more
doaj +1 more source
Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]
, 2010 Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H. +4 more
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Fine-Mapping an Association of FSHR with Preterm Birth in a Finnish Population
PLoS ONE, 2013 Preterm birth is a complex disorder defined by gestations of less than 37 weeks. While preterm birth is estimated to have a significant genetic component, relative few genes have been associated with preterm birth. Polymorphism in one such gene, follicle-stimulating hormone receptor (FSHR), has been associated with preterm birth in Finnish and African ...
Chun, Sung +4 more
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Atlas of Fshr Expression from Novel Reporter Mice
, 2023 Abstract The FSH-FSHR signaling pathway has traditionally been considered an essential regulator in reproductive development and fertility. But there has been emerging evidence of FSHR expression in extragonadal tissues/organs. This poses new questions and long-term debates regarding the physiological role of the FSH-FSHR pathway, and underscores the ...
Hong-Qian Chen +13 more
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Aquaculture ReportsThe Senegalese sole (Solea senegalensis) is a promising candidate for aquaculture diversification in southern Europe due to its favorable traits and high market value. However, reproductive challenges and sexual dimorphism in growth necessitate efficient
Emma Nicole Short +2 more
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LncRNA MRF targeting FSHR inhibits the osteogenic differentiation of BMSCs and bone defect repair through the regulation of the cAMP-PKA-CREB signaling pathway. [PDF]
Stem Cell Res TherNing Q +8 more
europepmc +2 more sources
Identification of novel candidate genes for follicle selection in the broiler breeder ovary [PDF]
, 2012 BACKGROUND: Broiler breeders fed ad libitum are characterised by multiple ovulation, which leads to poor shell quality and egg production. Multiple ovulation is controlled by food restriction in commercial flocks.
Dunn, Ian C +4 more
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