Results 151 to 160 of about 959 (203)

Anticoagulant and antithrombin activities of oversulfated fucans

Carbohydrate Research, 1992
Three species of oversulfated fucans having different sulfate contents (the ratio of sulfate/total sugar residues, 1.38-1.98) were prepared by chemical sulfation of a fucan sulfate (sulfate/sugar ratio, 1.28) isolated from the brown seaweed Ecklonia kurome.
T, Nishino, T, Nagumo
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A fucan specific lectin on teratocarcinoma stem cells

Biochemical and Biophysical Research Communications, 1981
Summary Teratocarcinoma stem cells have a cell surface carbohydrate-binding component detected by rosetting of intact stem cells with erythrocytes. We now report a soluble hemagglutination activity in stem cell extracts with a carbohydrate- and erythrocyte-binding specificity almost identical to that of the cell surface rosette-mediating factor.
L B, Grabel, C G, Glabe, M S, Singer, G R, Martin, S D, Rosen   +4 more
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Antiproliferative effect and interaction of fucans with cells

Colloids and Surfaces B: Biointerfaces, 1994
Abstract Fucans were extracted from the brown seaweed Ascophyllum nodosum , degraded by acidic hydrolysis, fractionated by gel nitration and characterized by high performance steric exclusion chromatography. Different fucan fractions of average molecular weight 6000–150000 g mol −1 were thus obtained. The effects of these low molecular weight (LMW)
Mostafa Ellouali, Catherine Boisson-Vidal, Jacqueline Jozefonvicz   +2 more
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A sulfated α-l-fucan from sea cucumber

Carbohydrate Research, 1994
A purified sulfated alpha-L-fucan from the sea cucumber body wall was studied, before and after almost complete desulfation, using methylation analysis and NMR spectroscopy. NMR analysis indicates that 2,4-di-O-sulfo-L-fucopyranose and unsubstituted fucopyranose are present in equal proportions, and that 2-O-sulfo-L-fucopyranose is present in twice ...
A C, Ribeiro, R P, Vieira, P A, Mourão, B, Mulloy   +3 more
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Relationship between Sulfate Groups and Biological Activities of Fucans

Thrombosis Research, 2000
The anticoagulant and antiproliferative effects of low molecular weight fucans with different sulfate content were examined. The anticoagulant activity was determined by activated partial thromboplastin time and the antiproliferative one was achieved in vitro on CCL39 fibroblast cell line.
F, Haroun-Bouhedja, M, Ellouali, C, Sinquin, C, Boisson-Vidal   +3 more
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Reversible disruption of cultured endothelial monolayers by sulphated fucans

Journal of Cell Science, 1983
ABSTRACT We have examined the effects of a variety of polysaccharides and glycoconjugates on the organization and morphology of cultured AI4CL-I endothelial monolayers. The sulphated fucose-containing polysaccharides, fucoidin and sea-urchin egg jelly fucan, induce a dramatic disruption of the organization of the monolayers ...
C G, Glabe, T, Yednock, S D, Rosen
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Fractionation and analysis of fucans from brown algae

Phytochemistry, 1990
Abstract Cell walls were isolated from the brown algae Pelvetia canaliculata, Fucus vesiculosus, Sargassum muticum (Fucales) and Laminaria digitata (Laminariales) and then submitted to sequential chemical extraction. Various fucans were isolated, i.e.
Mabeau, S., Kloareg, B., Joseleau, J.P.
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Relationship between antithrombotic activities of fucans and their structure

Drug Development Research, 2000
Abstract A low molecular weight fucan fraction extracted from the brown seaweed Ascophyllum nodosum was previously shown to exhibit dose‐related venous antithrombotic activity with an ED 80 of about 20 mg/kg, 2 h after a single ...
Catherine Boisson‐Vidal, Frederic Chaubet, Lionel Chevolot, Corinne Sinquin, Jocelyne Theveniaux, Jean Millet, Claude Sternberg, Barbara Mulloy, Anne Marie Fischer   +8 more
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Searching for Alternatives to Heparin Sulfated Fucans from Marine Invertebrates

Trends in Cardiovascular Medicine, 1999
We describe a variety of sulfated polysaccharides with regular and well-defined structures which are useful tools for elucidating structure/biological function relationship. Several of these compounds have anticoagulant and antithrombotic activities.
P A, Mourão, M S, Pereira
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Role of basic amino acids in the interaction of bindin with sulfated fucans

Biochemistry, 1988
Bindin, the acrosomal sperm adhesion protein of the sea urchin Strongylocentrotus purpuratus, binds specifically and with high affinity (Kd = 10(-8) M) to egg sulfated fucans in the high ionic strength milieu of seawater (0.55 M salt). Previous studies indicated that the negatively charged sulfate groups of the polysaccharide are critical for binding ...
P L, DeAngelis, C G, Glabe
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